ReviewAge (Dordrecht, Netherlands)2013
Reversing T cell immunosenescence: why, who, and how.
Review in Age (Dordrecht, Netherlands), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Exercise interventions for older adults: A systematic review of meta-analyses.Journal of sport and health science · 2021Pooled it
- Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- Effect of Aerobic-Based Exercise on Psychological Well-Being and Quality of Life Among Older People: A Middle East Study.Frontiers in public health · 2021Trial
- Differential effects of young and old hematopoietic stem cell niches on bone marrow-derived dendritic cells.Immunity & ageing : I & A · 2025Article
- Article
- The role of T cells in vascular aging, hypertension, and atherosclerosis.American journal of physiology. Heart and circulatory physiology · 2024Review
- Food allergies in older people: An emerging health problem.The World Allergy Organization journal · 2024Review
- Understanding the Complex Dynamics of Immunosenescence in Multiple Sclerosis: From Pathogenesis to Treatment.Biomedicines · 2024Review
- Incorporating frailty to address the key challenges to geriatric economic evaluation.BMC geriatrics · 2024Article
- sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence.Immunity & ageing : I & A · 2024Review
- Long-term outcome of natalizumab-associated progressive multifocal leukoencephalopathy in Austria: a nationwide retrospective study.Journal of neurology · 2024Article
- Comparison of Exergames Versus Conventional Exercises on the Health Benefits of Older Adults: Systematic Review With Meta-Analysis of Randomized Controlled Trials.JMIR serious games · 2023Review
- Article
- Biomodulina T (InmunyVitalFrontiers in immunology · 2020Article
- Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities.Malaria journal · 2019Article
- Research progress on immune aging and its mechanisms affecting geriatric diseases.Aging medicine (Milton (N.S.W)) · 2019Review
- Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments.International journal of molecular sciences · 2019Review
- T cell senescence and CAR-T cell exhaustion in hematological malignancies.Journal of hematology & oncology · 2018Review
- Aging and lymphocyte changes by immunomodulatory therapies impact PML risk in multiple sclerosis patients.Multiple sclerosis (Houndmills, Basingstoke, England) · 2018Review
- The potential of non-myeloablative heterochronous autologous hematopoietic stem cell transplantation for extending a healthy life span.GeroScience · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunosenescence is the term commonly used to describe the multifaceted phenomenon encompassing all changes occurring in the immune system during aging. It contributes to render older adults more prone to develop infectious disease and main age-related diseases. While age clearly imposes drastic changes in immune physiology, older adults have heterogeneous health and immune phenotypes. This confronts scientists and researcher to develop more age-specific interventions rather than simply adopting intervention regimes used in younger people and this in order to maintain immune protection in older adults. Thus, this review provides evidences of the central role played by cell-mediated immunity in the immunosenescence process and explores the means by which senescent state of the cell-mediated immune function could be identified and predicted using biomarkers. Furthermore considerations are given to recent advances made in the field of age-specific immune interventions that could contribute to maintain immune protection, to improve quality of life, and/or to promote healthy aging of the growing part of the population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.