ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Getting to the heart of the matter: age-related changes in diastolic heart function in the longest-lived rodent, the naked mole rat.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Longevity through immunity: the unusual naked mole-rat immune system.GeroScience · 2026Review
- Carcinogenesis resistance in the longest-lived rodent, the naked mole-rat.Cancer science · 2022Review
- Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life.GeroScience · 2022Article
- Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models.Frontiers in aging · 2022Review
- Alternative Animal Models of Aging Research.Frontiers in molecular biosciences · 2021Review
- Observational
- Cardiac metabolomic profile of the naked mole-rat-glycogen to the rescue.Biology letters · 2019Article
- Novel treatment strategies for chronic kidney disease: insights from the animal kingdom.Nature reviews. Nephrology · 2018Review
- The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent.Pflugers Archiv : European journal of physiology · 2017Article
- Breeding and Rearing Naked Mole-Rats (Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Unraveling the message: insights into comparative genomics of the naked mole-rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Regulation of Nrf2 signaling and longevity in naturally long-lived rodents.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models.Oxidative medicine and cellular longevity · 2015Review
- Questioning the preclinical paradigm: natural, extreme biology as an alternative discovery platform.Aging · 2014Review
- And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat.American journal of physiology. Heart and circulatory physiology · 2014Article
- Cardiac function of the naked mole-rat: ecophysiological responses to working underground.American journal of physiology. Heart and circulatory physiology · 2014Article
- The naked mole-rat response to oxidative stress: just deal with it.Antioxidants & redox signaling · 2013Review
- Within- and between-species study of extreme longevity--comments, commonalities, and goals.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The naked mole rat is an extremely long-lived (>31 years) small (35 g) rodent. Moreover, it maintains good health for most of its long life. We hypothesized that naked mole rats also show attenuated cardiac aging. With age, cardiac muscle can become less compliant, causing a decline in early diastolic filling (E) and a compensatory increase in atrial contraction-induced late filling (A). This results in decreased left ventricular E/A ratio. Doppler imaging showed no significant differences in E/A ratios (p = .48) among old (18-20 years) breeders and nonbreeders despite differences in estrogen levels. A cross-sectional study of 1- to 20-year-old naked mole rats (n = 76) revealed that E/A ratios declined with age in females (n = 40; p = .002) but not in males (n = 36; p = 0.45). Despite this, neither gender shows increased morbidity or mortality with age. These findings suggest that, notwithstanding the previously observed high lipid peroxidation in heart tissue, NMRs must possess mechanisms to stave off progression to fatal cardiac disease.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.