Evidence map›Paper›PMID 22367373›Full record

ArticleMolecular biology reports2012

UDP-glucuronosyltransferase 1A4 (UGT1A4) polymorphisms in a Jordanian population.

Nancy Hakooz, Sameh Alzubiedi, Al-Motassem Yousef, Tawfiq Arafat, Rana Dajani, Nidaa Ababneh, Said Ismail

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Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Nancy HakoozFaculty of Pharmacy, University of Jordan, Amman 11942, Jordan. nhakooz@ju.edu.jo
Sameh Alzubiedi
Al-Motassem Yousef
Tawfiq Arafat
Rana Dajani
Nidaa Ababneh
Said Ismail

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucuronidation is one of the most important phase II metabolic pathways. It is catalyzed by a family of UDP-glucuronosyltransferase enzymes (UGTs). One of the subfamilies is UGT1A. Allele frequencies in UGT1A4 differ among ethnic groups. The aim of this study was to determine the allelic frequency of two most common defective alleles: UGT1A4*2 and UGT1A4*3 in a Jordanian population. A total of 216 healthy Jordanian Volunteers (165 males and 51 females) were included in this study. Genotyping for UGT1A4*1, UGT1A4*2 and UGT1A4*3 was done using a well established polymerase chain reaction-restriction fragment length polymorphism test. Among 216 random individuals studied for UGT1A4*2 mutation there were 26 individuals who were heterozygous, giving a prevalence of 12% and an allele frequency of 6.5%. Only one individual was homozygous for UGT1A4*2. The UGT1A4*3 mutation was detected as heterozygous in 9 of 216 individuals indicating a prevalence of 4.2% and allele frequency of 3.5%. Three individuals were homozygous for the UGT1A4*3 indicating a prevalence of 1.4%. The prevalence of UGT1A4*2 is similar to the Caucasians but different from other populations whilst the UGT1A4*3 prevalence in the Jordanian population is distinct from other populations. Our results provide useful information for the Jordanian population and for future genotyping of Arab populations in general.

Indexed as

Gene FrequencyFemaleGenetic VariationGenotypeGlucuronosyltransferaseHumansJordanMalePolymorphism, Single Nucleotidebilirubin glucuronoside glucuronosyltransferaseGlucuronosyltransferase

Identifiers

PMID22367373

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