ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2013
Propofol exerts hippocampal neuron protective effects via up-regulation of metallothionein-3.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Research progress of propofol in alleviating cerebral ischemia/reperfusion injury.Pharmacological reports : PR · 2024Review
- Propofol alleviates cisplatin-related cognitive impairment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Angiotensin II-mediated suppression of synaptic proteins in mouse hippocampal neuronal HT22 cell was inhibited by propofol: role of calcium signaling pathway.Journal of anesthesia · 2018Article
- Neuroprotection by Propofol Post-Conditioning: Focus on PKMζ/KCC2 Pathway Activity.Cellular and molecular neurobiology · 2018Article
- Changes in intracellular copper concentration and copper-regulating gene expression after PC12 differentiation into neurons.Scientific reports · 2016Article
- Propofol Decreases Endoplasmic Reticulum Stress-Mediated Apoptosis in Retinal Pigment Epithelial Cells.PloS one · 2016Article
- New expression of 5-HT1A receptor in astrocytes in the gerbil hippocampal CA1 region following transient global cerebral ischemia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propofol is an intravenous anesthetic with neuroprotective effects against cerebral ischemia or hypoxia injury. However, the underlying mechanisms remain obscure. Recent years emerging evidence has demonstrated that metallothionein-3 (MT-3), a growth inhibitory factor that exists mainly in the central nervous system, exhibited neuroprotective effect in vivo. Here, we used a model of hypoxia/re-oxygenation (H/R) injury to examine the hippocampal neuroprotective effect of propofol, and explored the role of MT-3 in this action. H/R resulted in reduced cell viability and increased cell death in hippocampal neuron culture, as indicated by MTT assay and lactate dehydrogenase (LDH) release assay, respectively. Pretreatment of propofol at different concentrations (50, 150, and 250 μmol/L) reversed H/R-induced neurotoxicity and increased MT-3 mRNA and protein expressions. Moreover, propofol failed to exert neuroprotective effect when MT-3 was silenced by the transfection with the specific siRNA, suggesting that MT-3 was the crucial mediator for propofol's neuroprotective effect against H/R. In conclusion, our findings showed that propofol is neuroprotective in H/R model on hippocampal neuron cells and that it may act by up-regulation of MT-3.
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