ArticleMedical science monitor : international medical journal of experimental and clinical research2012
Effects of systemic ornidazole, systemic and local compound ornidazole and pefloxacin mesylate on experimental periodontitis in rats.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Lactobacillus sp. attenuates oral and hepatic alterations and decreases caspase-8 expression in ligature-induced periodontitis.Journal of applied oral science : revista FOB · 2026Article
- Dual nanozymes-loaded core-shell microneedle patches with antibacterial and NETs-degradation bifunctional properties for periodontitis treatment.Bioactive materials · 2025Article
- Development of liver disease caused by chronic periodontitis in rats.Journal of applied oral science : revista FOB · 2025Article
- Induced Periodontitis in Rats With Three Ligature Types: An Exploratory Study.Clinical and experimental dental research · 2024Article
- Long-Term and Stable Dental TherapiesACS omega · 2023Article
- Healing Enhancement Assessment of Thermosensitive in Situ Gelling Formulation Containing Metronidazole and Diclofenac Potassium for Ligature-induced Periodontitis in Rats.Oman medical journal · 2022Article
- Comparative Testing of Two Ligature-Induced Periodontitis Models in Rats: A Clinical, Histological and Biochemical Study.Biology · 2022Article
- A modified method for constructing experimental rat periodontitis model.Frontiers in bioengineering and biotechnology · 2022Article
- A novel Nanoformulation Development of Eugenol and their treatment in inflammation and periodontitis.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
- Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis.AMB Express · 2018Article
- One or two ligatures inducing periodontitis are sufficient to cause fatty liver.Medicina oral, patologia oral y cirugia bucal · 2018Article
- Evaluation of the efficacy ofBiomedical reports · 2018Article
- Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 expression.Acta pharmacologica Sinica · 2017Article
- Decrease of Pericytes is Associated With Liver Disease Caused by Ligature-Induced Periodontitis in Rats.Journal of periodontology · 2017Article
- Evaluation of the efficacy of 2% curcumin gel in the treatment of experimental periodontitis.Pharmacognosy research · 2014Article
- Evaluation of the efficacy of 2% Ocimum sanctum gel in the treatment of experimental periodontitis.International journal of pharmaceutical investigationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of the current study is to evaluate the effects of systemic ornidazole (SO) and systemic and local compound ornidazole and pefloxacin mesylate (SCOPM/LCOMP) on the inflammatory response associated with rat experimental chronic periodontitis (ECP) in sites with subgingival debridement. MATERIAL/
methodsPeriodontitis was induced in male Sprague-Dawley rats by placing a thin steel ligature around the upper first molars and inoculating them with Porphyromonas gingivalis 381. After the successful induction of the rat ECP, the periodontitis rats were randomly divided into 3 different combined treatment groups: (A) SO with scaling and root planing (SRP); (B) SCOMP with SRP; and (C) LCOMP with SRP. After 2 weeks the effects of the treatments were evaluated based on gingivitis, plaque index, probing pocket depth, aspartate aminotransferase, alveolar bone loss, and hematoxylin-eosin staining of the region around the first molars.
resultsAfter treatment, comparison with ECP was performed. The mean percentage reductions of SBI in SO, SCOPM, and LCOPM were 27.73%, 33.61%, and 58.82%, respectively. Those of PI were 33.20%, 42.80%, and 60.00%; those of PPD were 48.66%, 55.70%, and 72.48%; those of GCF-AST were 41.64%, 49.03%, and 66.42%; and those of ABL were 41.19%, 43.63%, and 54.47%, respectively. The inflammatory score of H&E showed median scores of 2.5, 1.75, 1.63, and 0.95 for ECP, SO, SCOMP, and LCOMP, respectively. All 3 treatment groups exhibited significantly reduced inflammation indicators (P<0.05). Of the 3, group C was the most effective (P<0.05).
conclusionsAlthough all the combined treatment groups responded to therapy with significant resolution of the infection, adjunctive LCOMP therapy is more effective for periodontitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.