ArticleMedical science monitor : international medical journal of experimental and clinical research2012
Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Comparison of blood tonic efficacy and chemical constituents of Kadsura interior A.C. Smith and its closely related species.Chinese medicine · 2022Article
- Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent.International journal of molecular sciences · 2021Review
- Hydrogen-Rich Water Ameliorates Murine Chronic Graft-versus-Host Disease through Antioxidation.Oxidative medicine and cellular longevity · 2021Article
- Review
- Article
- Therapeutic effects of hydrogen on chronic graft-versus-host disease.Journal of cellular and molecular medicine · 2017Article
- Effects of gamma rays on rat testis tissue according to the morphological parameters and immunohistochemistry: radioprotective role of silymarin.Electronic physician · 2017Article
- Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical.Oxidative medicine and cellular longevity · 2017Article
- Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Up-Regulation of microRNA-210 is Associated with Spermatogenesis by Targeting IGF2 in Male Infertility.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice.Oxidative medicine and cellular longevity · 2016Article
- Administration of hydrogen-rich saline in mice with allogeneic hematopoietic stem-cell transplantation.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles.Medical gas research · 2015Article
- A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine.Medical gas research · 2014Review
- Hydrogen therapy may be an effective and specific novel treatment for acute graft-versus-host disease (GVHD).Journal of cellular and molecular medicine · 2013Article
- Hydrogen as a new class of radioprotective agent.International journal of biological sciences · 2013Review
- Hydrogen therapy may be an effective and specific novel treatment for aplastic anemia.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Altered microRNA profiles of testicular biopsies from patients with nonobstructive azoospermia.Asian journal of andrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies show that molecular hydrogen (dihydrogen, H2) has potential as an effective and safe radioprotective agent through reducing oxidative stress. The aim of this study was to investigate whether H2 is able to protect spermatogenesis and hematopoiesis from radiation-induced injuries. MATERIAL/
methodsH2 was dissolved in physiological saline using an apparatus produced by our department. -60Co-gamma rays in the irradiation centre were used for irradiation. Spermatid head counts and histological analysis were used to evaluate spermatogenesis. Endogenous hematopoietic spleen colony formation (endoCFUs), bone marrow nucleated cells (BMNC) and peripheral blood (PB) leukocytes were used to evaluate hemopoiesis.
resultsThis study demonstrates that treating mice with H2 before ionizing radiation (IR) can increase the spermatid head count and protect seminiferous epithelium from IR. This study also demonstrates that H2 could significantly increase the number of endoCFUs, BMNC and PB leukocyte.
conclusionsThis study suggests that hydrogen-rich saline could partially protect spermatogenesis and hematopoiesis in irradiated mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.