ArticleMedical science monitor : international medical journal of experimental and clinical research2012
Aluminium sulphate exposure increases oxidative stress and suppresses brain development in Ross broiler chicks.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Review
- Role of Metabolic Genes in Blood Aluminum Concentrations of Jamaican Children with and without Autism Spectrum Disorder.International journal of environmental research and public health · 2016Article
- In ovo toxico-teratological effects of aluminum on embryonic chick heart and vascularization.Environmental science and pollution research international · 2016Article
- Protective effect of a calcium channel blocker "diltiazem" on aluminum chloride-induced dementia in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAluminium (Al) is known to have neurotoxic effects that can result in oxidative damage to a range of cellular biomolecules. These effects appear to be of significance in the developmental stages of the brain. We therefore investigated the oxidative and histopathological damage induced by Al during growth and development of the chick brain. MATERIAL/
methodsWe used a chick embryonic development model, with Al treatment of 500 µg Al sulphate in 0.1 ml saline injected into the egg air chambers at the beginning of their incubation period. The effects on chick-brain growth and development were then assessed at term (day 21). Determination of malondialdehyde and glutathione levels were used as relevant biological measures for increased oxidative stress in terms of lipid peroxidation and biochemical oxidative damage, respectively. Furthermore, we also monitored neuronal degeneration as estimated stereologically using the Cavalieri brain volume estimation tool.
resultsThis Al treatment showed significantly increased MDA levels and decreased GSH levels, as indicators of increased biochemical oxidative damage. This was accompanied by significantly decreased brain volume, as a measure of neuronal degeneration during brain development in this chick embryonic development model.
conclusionsExposure to Al during chick embryonic development results in increased oxidative stress in the brain that is accompanied by neuronal degeneration.
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