ReviewmBio2012
Mammalian-transmissible H5N1 influenza: facts and perspective.
Review in mBio, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment of serosurveys for H5N1.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Pooled it
- Distinguishing Swine Flu (H1N1) from COVID-19: Clinical, Virological, and Immunological Perspectives.Archives of microbiology & immunology · 2023Article
- Integrating evolutionary aspects into dual-use discussion: the cases of influenza virus and enterohemorrhagicEvolution, medicine, and public health · 2021Review
- Public awareness, acceptability and risk perception about infectious diseases dual-use research of concern: a cross-sectional survey.BMJ open · 2020Article
- A brief history of bird flu.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Does influenza pandemic preparedness and mitigation require gain-of-function research?Influenza and other respiratory viruses · 2017Article
- Joint China-US Call for Employing a Transdisciplinary Approach to Emerging Infectious Diseases.EcoHealth · 2015Article
- Adenovirus-mediated artificial MicroRNAs targeting matrix or nucleoprotein genes protect mice against lethal influenza virus challenge.Gene therapy · 2015Article
- Avian influenza H5 hemagglutinin binds with high avidity to sialic acid on different O-linked core structures on mucin-type fusion proteins.Glycoconjugate journal · 2014Article
- Synthetic biology and biosecurity: challenging the "myths".Frontiers in public health · 2014Article
- Does exposure to poultry and wild fowl confer immunity to H5N1?Chinese medical journal · 2014Article
- The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.Nature immunology · 2013Article
- Are we prepared to help low-resource communities cope with a severe influenza pandemic?Influenza and other respiratory viruses · 2013Review
- Highly pathogenic avian influenza A(H5N1) mutants transmissible by air are susceptible to human and animal neutralizing antibodies.The Journal of infectious diseases · 2013Article
- Engaging the normative question in the H5N1 avian influenza mutation experiments.Philosophy, ethics, and humanities in medicine : PEHM · 2013Article
- Editorial commentary: pandemic H5N1: receding risk or coming catastrophe?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Metagenomic analysis of the ferret fecal viral flora.PloS one · 2013Article
- Review
- Article
- H5N1 influenza virus seroepidemiological studies: the facts revisited.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two recently submitted (but as yet unpublished) studies describe success in creating mutant isolates of H5N1 influenza A virus that can be transmitted via the respiratory route between ferrets; concern has been raised regarding human-to-human transmissibility of these or similar laboratory-generated influenza viruses. Furthermore, the potential release of methods used in these studies has engendered a great deal of controversy around publishing potential dual-use data and also has served as a catalyst for debates around the true case-fatality rate of H5N1 influenza and the capability of influenza vaccines and antivirals to impact any future unintentional or intentional release of H5N1 virus. In this report, we review available seroepidemiology data for H5N1 infection and discuss how case-finding strategies may influence the overall case-fatality rate reported by the WHO. We also provide information supporting the position that if an H5N1 influenza pandemic occurred, available medical countermeasures would have limited impact on the associated morbidity and mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.