ArticlePlant physiology2012
Arabidopsis Hexokinase-Like1 and Hexokinase1 form a critical node in mediating plant glucose and ethylene responses.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 87 citations in OpenAlex.
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- Crosstalk Between Ethylene and JA/ABA/Sugar Signalling in Plants Under Physiological and Stress Conditions.Molecular plant pathology · 2025Review
- Genome-Wide Identification and Expression Analysis of Hexokinase Gene Family Under Abiotic Stress in Tomato.Plants (Basel, Switzerland) · 2025Article
- RAPID ALKALINIZATION FACTOR 22 is a key modulator of the root hair growth responses to fungal ethylene emissions in Arabidopsis.Plant physiology · 2024Article
- Sugar status in preexisting leaves determines systemic stomatal development within newly developing leaves.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Ubiquitin E3 ligase AtCHYR2 functions in glucose regulation of germination and post-germinative growth in Arabidopsis thaliana.Plant cell reports · 2023Article
- Comparative transcriptome analysis reveals key pathways and regulatory networks in early resistance ofFrontiers in microbiology · 2023Article
- De novo assembly and analysis of Polygonatum cyrtonema Hua and identification of genes involved in polysaccharide and saponin biosynthesis.BMC genomics · 2022Article
- Heat stress response in Chinese cabbage (PeerJ · 2022Article
- Molecular Targets and Biological Functions of cAMP Signaling inBiomolecules · 2021Article
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- Understanding salt tolerance mechanism using transcriptome profiling and de novo assembly of wild tomato Solanum chilense.Scientific reports · 2020Article
- Autophagy regulates glucose-mediated root meristem activity by modulating ROS production in Arabidopsis.Autophagy · 2019Article
- Review
- Label-free quantitative proteomics to investigate the response of strawberry fruit after controlled ozone treatment.RSC advances · 2019Article
- Transcriptome analysis ofPlant methods · 2019Article
- Trithorax-group protein ATX5 mediates the glucose response via impacting the HY1-ABI4 signaling module.Plant molecular biology · 2018Article
- The Sugar-Signaling Hub: Overview of Regulators and Interaction with the Hormonal and Metabolic Network.International journal of molecular sciences · 2018Review
- Effects of glucose and ethylene on root hair initiation and elongation in lettuce (Lactuca sativa L.) seedlings.Journal of plant research · 2018Article
- Complex Relationships between Chromatin Accessibility, Sequence Divergence, and Gene Expression in Arabidopsis thaliana.Molecular biology and evolution · 2018Article
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3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Arabidopsis (Arabidopsis thaliana) Hexokinase-Like1 (HKL1) lacks glucose (Glc) phosphorylation activity and has been shown to act as a negative regulator of plant growth. Interestingly, the protein has a largely conserved Glc-binding domain, and protein overexpression was shown previously to promote seedling tolerance to exogenous 6% (w/v) Glc. Since these phenotypes occur independently of cellular Glc signaling activities, we have tested whether HKL1 might promote cross talk between the normal antagonists Glc and ethylene. We show that repression by 1-aminocyclopropane-1-carboxylic acid (ACC) of the Glc-dependent developmental arrest of wild-type Arabidopsis seedlings requires the HKL1 protein. We also describe an unusual root hair phenotype associated with growth on high Glc medium that occurs prominently in HKL1 overexpression lines and in glucose insensitive 2-1 (gin2-1), a null mutant of Hexokinase1 (HXK1). Seedlings of these lines produce bulbous root hairs with an enlarged base after transfer from agar plates with normal medium to plates with 6% Glc. Seedling transfer to plates with 2% Glc plus ACC mimics the high-Glc effect in the HKL1 overexpression line but not in gin2-1. A similar ACC-stimulated, bulbous root hair phenotype also was observed in wild-type seedlings transferred to plates with 9% Glc. From transcript expression analyses, we found that HKL1 and HXK1 have differential roles in Glc-dependent repression of some ethylene biosynthesis genes. Since we show by coimmunoprecipitation assays that HKL1 and HXK1 can interact, these two proteins likely form a critical node in Glc signaling that mediates overlapping, but also distinct, cellular responses to Glc and ethylene treatments.
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