ArticleDevelopmental biology2012
The role of Irf6 in tooth epithelial invagination.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Tooth agenesis and orofacial clefting: genetic brothers in arms?Human genetics · 2016Pooled it
- Deep Phenotyping and Molecular Elucidation of a New Syndrome: Ectodermal Dysplasia Caused by IRF6 Variants.Experimental dermatology · 2026Article
- Novel Candidate Genes for Non-Syndromic Tooth Agenesis Identified Using Targeted Next-Generation Sequencing.Journal of clinical medicine · 2022Article
- Mutations in GDF11 and the extracellular antagonist, Follistatin, as a likely cause of Mendelian forms of orofacial clefting in humans.Human mutation · 2019Article
- The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation.Human molecular genetics · 2019Article
- A cleft lip and palate gene, Irf6, is involved in osteoblast differentiation of craniofacial bone.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- IRF6 and AP2A Interaction Regulates Epidermal Development.The Journal of investigative dermatology · 2018Article
- Interferon Regulatory Factor 6 Is Necessary for Salivary Glands and Pancreas Development.Journal of dental research · 2018Article
- Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate.Journal of dental research · 2017Article
- Full Spectrum of Postnatal Tooth Phenotypes in a Novel Irf6 Cleft Lip Model.Journal of dental research · 2016Article
- Toward an orofacial gene regulatory network.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Review
- Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium.Journal of dental research · 2015Article
- Three-dimensional analysis of the early development of the dentition.Australian dental journal · 2014Review
- Mouse Genetic Models Reveal Surprising Functions of IkB Kinase Alpha in Skin Development and Skin Carcinogenesis.Cancers · 2013Article
- From the transcription of genes involved in ectodermal dysplasias to the understanding of associated dental anomalies.Molecular syndromology · 2012Article
Corrections and comments
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Authors and funding
16 authors at 10 institutions in 4 countries.
Funding
Abstract
Thickening and the subsequent invagination of the epithelium are an important initial step in ectodermal organ development. Ikkα has been shown to play a critical role in controlling epithelial growth, since Ikkα mutant mice show protrusions (evaginations) of incisor tooth, whisker and hair follicle epithelium rather than invagination. We show here that mutation of the Interferon regulatory factor (Irf) family, Irf6 also results in evagination of incisor epithelium. In common with Ikkα mutants, Irf6 mutant evagination occurs in a NF-κB-independent manner and shows the same molecular changes as those in Ikkα mutants. Irf6 thus also plays a critical role in regulating epithelial invagination. In addition, we also found that canonical Wnt signaling is upregulated in evaginated incisor epithelium of both Ikkα and Irf6 mutant embryos.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.