ArticleJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons2012
Inductive, scaffold-based, regenerative medicine approach to reconstruction of the temporomandibular joint disk.
Article in Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 78 citations in OpenAlex.
- Scaffolds and Stem Cells Show Promise for TMJ Regeneration: A Systematic Review.Bioengineering (Basel, Switzerland) · 2026Review
- Comparison of cell-scaffold interactions in a biological and a synthetic wound matrix.International wound journal · 2025Article
- Auricular Chondrocytes as a Cell Source for Scaffold-Free Elastic Cartilage Tissue Engineering.Tissue engineering. Part C, Methods · 2024Article
- Trends of regenerative tissue engineering for oral and maxillofacial reconstruction in veterinary medicine.Frontiers in veterinary science · 2024Review
- Allogenic umbilical cord tissue for temporomandibular joint injuries.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc Substitution.Journal of functional biomaterials · 2022Article
- Inductive Remodeling of Extracellular Matrix Scaffolds in the Temporomandibular Joint of Pigs.Tissue engineering. Part A · 2022Article
- Synthetic materials in craniofacial regenerative medicine: A comprehensive overview.Frontiers in bioengineering and biotechnology · 2022Review
- Decellularized small intestine submucosa device for temporomandibular joint meniscus repair: Acute timepoint safety study.PloS one · 2022Article
- Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair.Journal of biomaterials applications · 2022Article
- Biological Treatments for Temporomandibular Joint Disc Disorders: Strategies in Tissue Engineering.Biomolecules · 2021Review
- Regenerative Potential of Mandibular Condyle Cartilage and Bone Cells Compared to Costal Cartilage Cells When Seeded in Novel Gelatin Based Hydrogels.Annals of biomedical engineering · 2021Article
- Research progress on tissue engineering in repairing tempomandibular joint.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2021Article
- Biological dermal templates with native collagen scaffolds provide guiding ridges for invading cells and may promote structured dermal wound healing.International wound journal · 2020Article
- Multi-Material Implants for Temporomandibular Joint Disc Repair: Tailored Additive Manufacturing Production.Frontiers in bioengineering and biotechnology · 2020Article
- Effect of Measurement Technique on TMJ Mandibular Condyle and Articular Disc Morphometry: CBCT, MRI, and Physical Measurements.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2019Article
- Tissue Engineering for the Temporomandibular Joint.Advanced healthcare materials · 2019Review
- Considerations for translation of tissue engineered fibrocartilage from bench to bedside.Journal of biomechanical engineering · 2018Article
- Fibro/chondrogenic differentiation of dental stem cells into chitosan/alginate scaffolds towards temporomandibular joint disc regeneration.Journal of materials science. Materials in medicine · 2018Article
- Tissue engineering toward temporomandibular joint disc regeneration.Science translational medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeA device composed of extracellular matrix (ECM) was investigated as an inductive template in vivo for reconstruction of the temporomandibular joint (TMJ) disk after discectomy. MATERIALS AND
methodsA scaffold material composed of porcine-derived ECM was configured to mimic the shape and size of the TMJ. This device was implanted in a canine model of bilateral TMJ discectomy. After discectomy, 1 side was repaired with an ECM scaffold material and the contralateral side was left empty as a control. At 6 months after implantation, the joint space was opened, the joints were evaluated for signs of gross pathologic degenerative changes, and newly formed tissue was excised for histologic, biochemical, and biomechanical analysis.
resultsThe results showed that implantation of an initially acellular material supported the formation of site-appropriate, functional host tissue that resembled that of the native TMJ disk. Furthermore, this prevented gross degenerative changes in the temporal fossa and mandibular condyle. No tissue formation and mild to severe gross pathologic changes were observed in the contralateral controls.
conclusionsThese results suggest that an ECM-based bioscaffold could represent an off-the-shelf solution for TMJ disk replacement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.