ArticleClinical nutrition (Edinburgh, Scotland)2012
Higher serum concentrations of dietary antioxidants are associated with lower levels of inflammatory biomarkers during the year after hip fracture.
Article in Clinical nutrition (Edinburgh, Scotland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Observational
- Extracellular Water and Phase Angle, Markers of Heightened Inflammatory State, and Their Extrapolative Potential for Body Composition Outcomes in Adults.Metabolites · 2026Article
- Dietary antioxidants associated with slower progression of parkinsonian signs in older adults.Nutritional neuroscience · 2022Article
- Carotenoids: Therapeutic Strategy in the Battle against Viral Emerging Diseases, COVID-19: An Overview.Preventive nutrition and food science · 2021Review
- Circulating Alpha-Tocopherol Levels, Bone Mineral Density, and Fracture: Mendelian Randomization Study.Nutrients · 2021Article
- Focus on Pivotal Role of Dietary Intake (Diet and Supplement) and Blood Levels of Tocopherols and Tocotrienols in Obtaining Successful Aging.International journal of molecular sciences · 2015Review
- Intake of antioxidants and subsequent decline in physical function in a racially/ethnically diverse population.The journal of nutrition, health & aging · 2015Article
- Article
- Vitamin D deficiency associates with γ-tocopherol and quadriceps weakness but not inflammatory cytokines in subjects with knee osteoarthritis.Redox biology · 2014Article
- Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies.The American journal of clinical nutrition · 2014Observational
- Low levels of plasma carotenoids are associated with an increased risk of atrial fibrillation.European journal of epidemiology · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
BACKGROUND &
aimsChronic inflammation impairs recovery among the 1.6 million people who suffer from hip fracture annually. Vitamin E and the carotenoids are two classes of dietary antioxidants with profound anti-inflammatory effects, and the goal of this study was to assess whether higher post-fracture concentrations of these antioxidants were associated with lower levels of interleukin 6 (IL-6) and the soluble receptor for tumor necrosis factor-alpha (sTNF-αR1), two common markers of inflammation.
methodsSerum concentrations of the dietary antioxidants and inflammatory markers were assessed at baseline and 2, 6, and 12 month follow-up visits among 148 hip fracture patients from The Baltimore Hip Studies. Generalized estimating equations modeled the relationship between baseline and time-varying antioxidant concentrations and inflammatory markers.
resultsHigher post-fracture concentrations of vitamin E and the carotenoids were associated with lower levels of inflammatory markers. Associations were strongest at baseline, particularly between the α-tocopherol form of vitamin E and sTNF-αR1 (p = 0.05) and total carotenoids and both sTNF-αR1(p = 0.01) and IL-6 (p = 0.05). Higher baseline and time-varying α-carotene and time-varying lutein concentrations were also associated with lower sTNF-αR1 at all post-fracture visits (p ≤ 0.05).
conclusionsThese findings suggest that a clinical trial increasing post-fracture intake of vitamin E and the carotenoids may be warranted.
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