ArticleNeuron2012
Encoding of luminance and contrast by linear and nonlinear synapses in the retina.
Article in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Quantifying the link between retinal performance and the optomotor response.Current biology : CB · 2025Article
- Substance P and dopamine form a "push-pull" system that diurnally regulates retinal gain.Current biology : CB · 2024Article
- A Novel Cre Recombinase Mouse Strain for Cell-Specific Deletion of Floxed Genes in Ribbon Synapse-Forming Retinal Neurons.International journal of molecular sciences · 2024Article
- Defining morphologically and genetically distinct GABAergic/cholinergic amacrine cell subtypes in the vertebrate retina.PLoS biology · 2024Article
- Molecular Logic of Synaptic Diversity BetweenbioRxiv : the preprint server for biology · 2023Article
- The Impact of Multivesicular Release on the Transmission of Sensory Information by Ribbon Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina.Nature communications · 2022Article
- Diurnal changes in the efficiency of information transmission at a sensory synapse.Nature communications · 2022Article
- Article
- A theoretical model reveals specialized synaptic depressions and temporal frequency tuning in retinal parallel channels.Frontiers in computational neuroscience · 2022Article
- Functional development and regeneration of hair cells in the zebrafish lateral line.The Journal of physiology · 2021Article
- A sensory cell diversifies its output by varying CaThe EMBO journal · 2021Article
- Retrograde Mitochondrial Transport Is Essential for Organelle Distribution and Health in Zebrafish Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Motor Behavior Selectively Inhibits Hair Cells Activated by Forward Motion in the Lateral Line of Zebrafish.Current biology : CB · 2020Article
- High Contrast Allows the Retina to Compute More Than Just Contrast.Frontiers in cellular neuroscience · 2020Article
- Article
- An amplitude code transmits information at a visual synapse.Nature neuroscience · 2019Article
- Article
- The Transfer Characteristics of Hair Cells Encoding Mechanical Stimuli in the Lateral Line of Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Synaptically silent sensory hair cells in zebrafish are recruited after damage.Nature communications · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Understanding how neural circuits transmit information is technically challenging because the neural code is contained in the activity of large numbers of neurons and synapses. Here, we use genetically encoded reporters to image synaptic transmission across a population of sensory neurons-bipolar cells in the retina of live zebrafish. We demonstrate that the luminance sensitivities of these synapses varies over 10(4) with a log-normal distribution. About half the synapses made by ON and OFF cells alter their polarity of transmission as a function of luminance to generate a triphasic tuning curve with distinct maxima and minima. These nonlinear synapses signal temporal contrast with greater sensitivity than linear ones. Triphasic tuning curves increase the dynamic range over which bipolar cells signal light and improve the efficiency with which luminance information is transmitted. The most efficient synapses signaled luminance using just 1 synaptic vesicle per second per distinguishable gray level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.