ArticleNeuron2012
A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation.
Article in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 100 citations in OpenAlex.
- Leptomeninges: Anatomy, Mechanisms of Disease and Neuroimaging.Neurology international · 2025Review
- Duropathies: A Narrative Overview of a Neglected Concept-Part One: Anatomical, Embryological, and Pathophysiological Elements.NeuroSci · 2025Review
- Apelin as a CNS-specific pathway for fenestrated capillary formation in the choroid plexus.Nature communications · 2025Article
- Article
- Meningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2.Cell reports · 2025Article
- Demyelination and impaired oligodendrogenesis in the corpus callosum following lead exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy.Cancer discovery · 2024Article
- Loss of Twist1 and balanced retinoic acid signaling from the meninges causes cortical folding in mice.Development (Cambridge, England) · 2023Article
- Novel model of cortical-meningeal organoid co-culture system improves human cortical brain organoid cytoarchitecture.Scientific reports · 2023Article
- Stuck on you: Meninges cellular crosstalk in development.Current opinion in neurobiology · 2023Review
- Torcular pseudomass is frequently detected on fetal magnetic resonance imaging and reduces with gestational age.Pediatric radiology · 2023Review
- Impact of aging on meningeal gene expression.Fluids and barriers of the CNS · 2023Article
- Molecular mechanisms of corpus callosum development: a four-step journey.Frontiers in neuroanatomy · 2023Review
- CaCell death & disease · 2022Article
- Major brain malformations: corpus callosum dysgenesis, agenesis of septum pellucidum and polymicrogyria in patients with BCORL1-related disorders.Journal of human genetics · 2022Article
- Vascular Regulation of Developmental Neurogenesis.Frontiers in cell and developmental biology · 2022Review
- Meninges: A Widespread Niche of Neural Progenitors for the Brain.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021Review
- Single-cell atlas reveals meningeal leukocyte heterogeneity in the developing mouse brain.Genes & development · 2021Article
- The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses.Development (Cambridge, England) · 2021Article
- Neurological Phenotype of Mowat-Wilson Syndrome.Genes · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The corpus callosum is the most prominent commissural connection between the cortical hemispheres, and numerous neurodevelopmental disorders are associated with callosal agenesis. By using mice either with meningeal overgrowth or selective loss of meninges, we have identified a cascade of morphogenic signals initiated by the meninges that regulates corpus callosum development. The meninges produce BMP7, an inhibitor of callosal axon outgrowth. This activity is overcome by the induction of expression of Wnt3 by the callosal pathfinding neurons, which antagonize the inhibitory effects of BMP7. Wnt3 expression in the cingulate callosal pathfinding axons is developmentally regulated by another BMP family member, GDF5, which is produced by the adjacent Cajal-Retzius neurons and turns on before outgrowth of the callosal axons. The effects of GDF5 are in turn under the control of a soluble GDF5 inhibitor, Dan, made by the meninges. Thus, the meninges and medial neocortex use a cascade of signals to regulate corpus callosum development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.