Axonal mRNA translation: an unexpected link to axon survival and the mitochondrion.

Nicolas Preitner, John G Flanagan

Open access · bronzeAbstract readComment

In one paragraph

Article in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

0.1field-weighted citation impact, top 48% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states.PloS one · 2021
Article
Homeoprotein transduction in neurodevelopment and physiopathology.Science advances · 2020
Review
Local Translation in Growth Cones and Presynapses, Two Axonal Compartments for Local Neuronal Functions.Biomolecules · 2020
Review
Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production.Heliyon · 2018
Article

4 · The record

Corrections and comments

Comment on
Local translation of extranuclear lamin B promotes axon maintenance.2012

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nicolas PreitnerDepartment of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston MA 02115, USA. nicolas_preitner@hms.harvard.edu

John G Flanagan

Harvard University · US

Funding

CELL-CELL SIGNALING IN VISUAL DEVELOPMENTR01EY011559 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI FLANAGAN, JOHN G · 1996 to 2016

$6.9M

Signal transduction in axon guidanceR01NS069913 · NINDS · HARVARD MEDICAL SCHOOL · PI John G Flanagan · 2011 to 2026

$4.5M

Identification and Function of Receptors and LigandsR37HD029417 · NICHD · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI FLANAGAN, JOHN G · 2002 to 2011

$4.0M

NEI NIH HHS R01 EY011559NICHD NIH HHS R37 HD029417NINDS NIH HHS R01 NS069913

6 · The paper itself

Abstract

Localized mRNA translation plays roles in dendrites and axons, but the regulatory mechanisms and downstream pathways are not well understood. An article in Cell by Yoon et al. (2012) shows that lamin B2, well known as a nuclear protein, undergoes regulated synthesis in axons, promoting mitochondrial function and axon survival.

Identifiers

PMID22365539

DOI10.1016/j.neuron.2012.02.005

PMCPMC3712866

OpenAlexW2041222816

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.