ArticleJournal of biomechanics2012
Which diameter and angle rule provides optimal flow patterns in a coronary bifurcation?
Article in Journal of biomechanics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 95 citations in OpenAlex.
- Comparison of 6-month vascular healing response after bioresorbable polymer versus durable polymer drug-eluting stent implantation in patients with acute coronary syndromes: A randomized serial optical coherence tomography study.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2021Trial
- Non-Invasive functional assessment of severity in cerebral arterial stenosis using cerebral flow fraction: A hemodynamic study.Medical & biological engineering & computing · 2026Article
- The influence of reverse flow within side branches on plaque formation relative to coronary bifurcation angles.Scientific reports · 2025Article
- Sensitivity of coronary hemodynamics to vascular structure variations in health and disease.Scientific reports · 2025Article
- Integrated multidisciplinary approach to aneurysm hemodynamic analysis: numerical simulation,Frontiers in bioengineering and biotechnology · 2025Review
- Volumetric Stent Expansion Index to Assess Tapering Lesions Using Intravascular Ultrasound and Its Clinical Outcomes.Reviews in cardiovascular medicine · 2024Article
- Review of Progress in Interventional Therapy for Coronary Bifurcation Lesions.Reviews in cardiovascular medicine · 2024Review
- Stent expansion evaluated by optical coherence tomography and subsequent outcomes.Scientific reports · 2023Article
- DEFINITION criteria for left main bifurcation stenting - from clinical need to a formula.AsiaIntervention · 2023Review
- Multislice computerized tomography coronary angiography can be a comparable tool to intravascular ultrasound in evaluating "true" coronary artery bifurcations.Frontiers in cardiovascular medicine · 2023Article
- Article
- Patient-specific computational simulation of coronary artery bifurcation stenting.Scientific reports · 2021Article
- Local fluid dynamics in patients with bifurcated coronary lesions undergoing percutaneous coronary interventions.Cardiology journal · 2021Review
- Efficacy of coronary imaging on bifurcation intervention.Cardiovascular intervention and therapeutics · 2021Review
- Tumor vascular status controls oxygen delivery facilitated by infused polymerized hemoglobins with varying oxygen affinity.PLoS computational biology · 2020Article
- Bioprinting Vasculature: Materials, Cells and Emergent Techniques.Materials (Basel, Switzerland) · 2019Review
- Bifurcation Asymmetry of Small Coronary Arteries in Juvenile and Adult Mice.Frontiers in physiology · 2018Article
- A comparison of postoperative morphometric and hemodynamic changes between saphenous vein and left internal mammary artery grafts.Physiological reports · 2017Article
- A Study of Coronary Bifurcation Shape in a Normal Population.Journal of cardiovascular translational research · 2017Article
- Image-based quantification of 3D morphology for bifurcations in the left coronary artery: Application to stent design.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The branching angle and diameter ratio in epicardial coronary artery bifurcations are two important determinants of atherogenesis. Murray's cubed diameter law and bifurcation angle have been assumed to yield optimal flows through a bifurcation. In contrast, we have recently shown a 7/3 diameter law (HK diameter model), based on minimum energy hypothesis in an entire tree structure. Here, we derive a bifurcation angle rule corresponding to the HK diameter model and critically evaluate the streamline flow through HK and Murray-type bifurcations. The bifurcations from coronary casts were found to obey the HK diameter model and angle rule much more than Murray's model. A finite element model was used to investigate flow patterns for coronary artery bifurcations of various types. The inlet velocity and pressure boundary conditions were measured by ComboWire. Y-bifurcation of Murray type decreased wall shear stress-WSS (10%-40%) and created an increased oscillatory shear index-OSI in atherosclerosis-prone regions as compared with HK-type bifurcations. The HK-type bifurcations were found to have more optimal flow patterns (i.e., higher WSS and lower OSI) than Murray-type bifurcations which have been traditionally believed to be optimized. This study has implications for changes in bifurcation angles and diameters in percutaneous coronary intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.