ArticleJournal of the American Academy of Child and Adolescent Psychiatry2012
Amygdala hyperactivation during face emotion processing in unaffected youth at risk for bipolar disorder.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Common and distinct neural correlates of emotional processing in individuals at familial risk for major depressive disorder and bipolar disorder: A comparative meta-analysis.Journal of affective disorders · 2024Pooled it
- Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: A review of the literature.Neuroscience and biobehavioral reviews · 2016Pooled it
- Fish oil supplementation alters emotion-generated corticolimbic functional connectivity in depressed adolescents at high-risk for bipolar I disorder: A 12-week placebo-controlled fMRI trial.Bipolar disorders · 2022Trial
- Emotion-Related Network Reorganization Following Fish Oil Supplementation in Depressed Bipolar Offspring: An fMRI Graph-Based Connectome Analysis.Journal of affective disorders · 2021Trial
- Early intervention for youth at high risk for bipolar disorder: A multisite randomized trial of family-focused treatment.Early intervention in psychiatry · 2019Trial
- Fronto-limbic function in unaffected offspring at familial risk for bipolar disorder during an emotional working memory paradigm.Developmental cognitive neuroscience · 2013Trial
- Functional connectivity of the nucleus accumbens and the amygdala in offspring of parents with bipolar or major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- Article
- Putative Risk Biomarkers of Bipolar Disorder in At-risk Youth.Neuroscience bulletin · 2024Review
- Brain functional activation and first mood episode in youth at risk for bipolar disorder.Journal of affective disorders · 2023Article
- The impact of pandemic-related stress on attentional bias and anxiety in alexithymia during the COVID-19 pandemic.Scientific reports · 2023Article
- Human emotion processing accuracy, negative biases, and fMRI activation are associated with childhood trauma.Frontiers in psychiatry · 2023Article
- Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings.Molecular psychiatry · 2022Review
- Emotion Processing Deficit in Euthymic Bipolar Disorder: A Potential Endophenotype.Indian journal of psychological medicine · 2022Article
- Neural Correlates of Positive Emotion Processing That Distinguish Healthy Youths at Familial Risk for Bipolar Versus Major Depressive Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
- Neural function during emotion regulation and future depressive symptoms in youth at risk for affective disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Evaluating endophenotypes for bipolar disorder.International journal of bipolar disorders · 2021Review
- The use of component-wise gradient boosting to assess the possible role of cognitive measures as markers of vulnerability to pediatric bipolar disorder.Cognitive neuropsychiatry · 2019Article
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9 authors.
Funding
Abstract
objectiveYouth at familial risk for bipolar disorder (BD) show deficits in face emotion processing, but the neural correlates of these deficits have not been examined. This preliminary study tests the hypothesis that, relative to healthy comparison (HC) subjects, both BD subjects and youth at risk for BD (i.e., those with a first-degree BD relative) will demonstrate amygdala hyperactivation when viewing fearful and happy faces. The at-risk youth were unaffected, in that they had no history of mood disorder.
methodAmygdala activity was examined in 101 unrelated participants, 8 to 18 years old. Age, gender, and IQ-matched groups included BD (N = 32), unaffected at-risk (N = 13), and HC (N = 56). During functional magnetic resonance imaging, participants attended to emotional and nonemotional aspects of fearful and happy faces.
resultsWhile rating their fear of fearful faces, both BD and unaffected at-risk subjects exhibited amygdala hyperactivity versus HC. There were no between-group differences in amygdala activity in response to happy faces. Post-hoc comparisons revealed that, in at-risk youth, familial risk status (offspring versus sibling), presence of Axis I diagnosis (n = 1 attention-deficit/hyperactivity disorder [ADHD], n = 1 social phobia), and history of medication exposure (n = 1) did not influence imaging findings.
conclusionsWe found amygdala hyperactivation in both unaffected at-risk and BD youth while rating their fear of fearful faces. These pilot data suggest that both face emotion labeling deficits and amygdala hyperactivity during face processing should receive further study as potential BD endophenotypes. Longitudinal studies should test whether amygdala hyperactivity to fearful faces predicts conversion to BD in at-risk youth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.