ArticlePain2012
Imaging the neural correlates of neuropathic pain and pleasurable relief associated with inherited erythromelalgia in a single subject with quantitative arterial spin labelling.
Article in Pain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02672059 (Pain In Neuropathy Study), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pain In Neuropathy Study
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Mepyramine targets mutant Nav1.7 channels to relieve pain and erythema in primary erythromelalgia patients.Frontiers in medicine · 2025Article
- Neanderthal introgression in SCN9A impacts mechanical pain sensitivity.Communications biology · 2023Article
- Imaging Clinically Relevant Pain States Using Arterial Spin Labeling.Pain reports · 2019Article
- Review
- Primary erythromelalgia: a review.Orphanet journal of rare diseases · 2015Review
- Article
- The clinical approach to small fibre neuropathy and painful channelopathy.Practical neurology · 2014Review
- Mexiletine as a treatment for primary erythromelalgia: normalization of biophysical properties of mutant L858F NaV 1.7 sodium channels.British journal of pharmacology · 2014Article
- Lost but making progress--Where will new analgesic drugs come from?Science translational medicine · 2014Review
- Pain vulnerability: a neurobiological perspective.Nature neuroscience · 2014Review
- Imaging pain: a potent means for investigating pain mechanisms in patients.British journal of anaesthesia · 2013Review
- Novel mutations mapping to the fourth sodium channel domain of Nav1.7 result in variable clinical manifestations of primary erythromelalgia.Neuromolecular medicine · 2013Article
- Default mode network connectivity encodes clinical pain: an arterial spin labeling study.Pain · 2013Article
- Genes and epigenetic processes as prospective pain targets.Genome medicine · 2013Review
- Imaging pain in arthritis: advances in structural and functional neuroimaging.Current pain and headache reports · 2012Review
- Brain activity associated with pain in inherited erythromelalgia: stimulus-free pain engages brain areas involved in valuation and learning.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Na(v)1.7. The patient reported severe ongoing foot pain, which was exquisitely sensitive to limb cooling. We confirmed this heat hypersensitivity using quantitative sensory testing. Additionally, we employed a novel perfusion imaging technique in a simple block design to assess her baseline erythromelalgia pain vs cooling relief. Robust activations of key pain, pain-affect, and reward-related centres were observed. This combined approach allowed us to confirm the presence of a temperature-sensitive channelopathy of peripheral neurons and to investigate the neural correlates of tonic neuropathic pain and relief in a single subject.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.