ArticleSchizophrenia research2012
Cortical gyrification in velo-cardio-facial (22q11.2 deletion) syndrome: a longitudinal study.
Article in Schizophrenia research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Neuroimaging Phenotypes Associated With Risk and Resilience for Psychosis and Autism Spectrum Disorders in 22q11.2 Microdeletion Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- Abnormalities in white matter tracts in the fronto-striatal-thalamic circuit are associated with verbal performance in 22q11.2DS.Schizophrenia research · 2020Article
- Patterns of Cortical Folding Associated with Autistic Symptoms in Carriers and Noncarriers of the 22q11.2 Microdeletion.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Cortical Complexity in People at Ultra-High-Risk for Psychosis Moderated by Childhood Trauma.Frontiers in psychiatry · 2020Article
- Neurobiological perspective of 22q11.2 deletion syndrome.The lancet. Psychiatry · 2019Review
- Longitudinal perspectives on the psychosis spectrum in 22q11.2 deletion syndrome.American journal of medical genetics. Part A · 2018Review
- Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis.Journal of child psychology and psychiatry, and allied disciplines · 2017Article
- Quantifying indices of short- and long-range white matter connectivity at each cortical vertex.PloS one · 2017Article
- Article
- Aberrant Cortical Morphometry in the 22q11.2 Deletion Syndrome.Biological psychiatry · 2015Article
- The development of cognitive control in children with chromosome 22q11.2 deletion syndrome.Frontiers in psychology · 2014Article
- A cross-sectional analysis of the development of response inhibition in children with chromosome 22q11.2 deletion syndrome.Frontiers in psychiatry · 2013Article
- 22q11 deletion syndrome: a review of the neuropsychiatric features and their neurobiological basis.Neuropsychiatric disease and treatment · 2013Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
introductionVelo-cardio-facial syndrome (VCFS) has been identified as an important risk factor for psychoses, with up to 32% of individuals with VCFS developing a psychotic illness. Individuals with VCFS thus form a unique group to identify and explore early symptoms and biological correlates of psychosis. In this study, we examined if cortical gyrification pattern, i.e. gyrification index (GI) can be a potential neurobiological marker for psychosis.
methodGIs of 91 individuals with VCFS were compared with 29 siblings and 54 controls. Further, 58 participants with VCFS, 21 siblings and 18 normal controls were followed up after 3 years and longitudinal changes in GI were compared. Additionally, we also correlated longitudinal changes in GI in individuals with VCFS with prodromal symptoms of psychosis on the Scale of Prodromal Symptoms (SOPS).
resultIndividuals with VCFS had significantly lower GIs as compared to their siblings and normal controls. Longitudinal examination of GI did not reveal any significant group-time interactions between the three groups. Further, longitudinal change in GI scores in the VCFS group was negatively correlated with positive prodromal symptoms, with the left occipital region reaching statistical significance.
conclusionThe study confirms previous reports that individuals with VCFS have reduced cortical folding as compared to normal controls. However over a period of three years, there is no difference in the rate of change of GI among both individuals with VCFS and normal controls. Finally, our results suggest that neuroanatomical alterations in areas underlying visual processing may be an early marker for psychosis.
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