ArticleTrends in genetics : TIG2012
Does stress induce (para)sex? Implications for Candida albicans evolution.
Article in Trends in genetics : TIG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 86 citations in OpenAlex.
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways.Science China. Life sciences · 2023Article
- Love in the time of climate change: A review of sexual reproduction in the order Onygenales.Fungal genetics and biology : FG & B · 2023Review
- Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens.BMC biology · 2023Article
- Article
- Reproduction response of Colletotrichum fungi under the fungicide stress reveals new aspects of chemical control of fungal diseases.Microbial biotechnology · 2022Article
- Increased Virulence and Large-Scale Reduction in Genome Size of TetraploidFrontiers in fungal biology · 2022Article
- Parasexuality ofFrontiers in cellular and infection microbiology · 2021Review
- Virulence phenotypes result from interactions between pathogen ploidy and genetic background.Ecology and evolution · 2020Article
- Article
- Host-Induced Genome Instability Rapidly Generates Phenotypic Variation across Candida albicans Strains and Ploidy States.mSphere · 2020Article
- Genomic evidence for a hybrid origin of the yeast opportunistic pathogen Candida albicans.BMC biology · 2020Article
- Unraveling HowJournal of fungi (Basel, Switzerland) · 2020Review
- The Magnitude ofG3 (Bethesda, Md.) · 2019Article
- Review
- Phased Diploid Genome Assemblies for Three Strains ofG3 (Bethesda, Md.) · 2019Article
- Review
- Environment-induced same-sex mating in the yeast Candida albicans through the Hsf1-Hsp90 pathway.PLoS biology · 2019Article
- Article
- Frequent ploidy changes in growing yeast cultures.Current genetics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Theory predicts that stress is a key factor in explaining the evolutionary role of sex in facultatively sexual organisms, including microorganisms. Organisms capable of reproducing both sexually and asexually are expected to mate more frequently when stressed, and such stress-induced mating is predicted to facilitate adaptation. Here, we propose that stress has an analogous effect on the parasexual cycle in Candida albicans, which involves alternation of generations between diploid and tetraploid cells. The parasexual cycle can generate high levels of diversity, including aneuploidy, yet it apparently occurs only rarely in nature. We review the evidence that stress facilitates four major steps in the parasexual cycle and suggest that parasex occurs much more frequently under stress conditions. This may explain both the evolutionary significance of parasex and its apparent rarity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.