ReviewInternational review of cell and molecular biology2012
Mechanism of function of viral channel proteins and implications for drug development.
Review in International review of cell and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Comparative Genomics of Viral Genomes and Identification of Three Novel Viroporin-Like Superfamilies.Microbial physiology · 2026Article
- Data hazards in synthetic biology.Synthetic biology (Oxford, England) · 2024Review
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- Decoupled side chain and backbone dynamics for proton translocation - M2 of influenza A.Journal of molecular modeling · 2017Article
- Viral channel forming proteins--How to assemble and depolarize lipid membranes in silico.Biochimica et biophysica acta · 2016Review
- Membrane protein assembly: two cytoplasmic phosphorylated serine sites of Vpu from HIV-1 affect oligomerization.Scientific reports · 2016Article
- Targeting the Channel Activity of Viroporins.Advances in protein chemistry and structural biology · 2016Review
- Mechanism of influenza A M2 transmembrane domain assembly in lipid membranes.Scientific reports · 2015Article
- Review
- Genotype-specific differences in structural features of hepatitis C virus (HCV) p7 membrane protein.Biochimica et biophysica acta · 2015Article
- Structure based computational assessment of channel properties of assembled ORF-8a from SARS-CoV.Proteins · 2015Article
- Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus.Planta medica · 2014Article
- Reliability of nine programs of topological predictions and their application to integral membrane channel and carrier proteins.Journal of molecular microbiology and biotechnology · 2014Article
- Assembling an ion channel: ORF 3a from SARS-CoV.Biopolymers · 2013Article
- Possible Potential Effects of Honey and Its Main Components Against Covid-19 Infection.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral channel-forming proteins comprise a class of viral proteins which, similar to their host companions, are made to alter electrochemical or substrate gradients across lipid membranes. These proteins are active during all stages of the cellular life cycle of viruses. An increasing number of proteins are identified as channel proteins, but the precise role in the viral life cycle is yet unknown for the majority of them. This review presents an overview about these proteins with an emphasis on those with available structural information. A concept is introduced which aligns the transmembrane domains of viral channel proteins with those of host channels and toxins to give insights into the mechanism of function of the viral proteins from potential sequence identities. A summary of to date investigations on drugs targeting these proteins is given and discussed in respect of their mode of action in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.