ArticleBMC public health2012
Impact of metabolic comorbidity on the association between body mass index and health-related quality of life: a Scotland-wide cross-sectional study of 5,608 participants.
Article in BMC public health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mental health and quality of life in different obesity phenotypes: a systematic review.Health and quality of life outcomes · 2022Pooled it
- A systematic review of reviews: exploring the relationship between obesity, weight loss and health-related quality of life.Clinical obesity · 2017Pooled it
- Weight loss is associated with improved quality of life among rural women completers of a web-based lifestyle intervention.PloS one · 2019Trial
- Increasing BMI is associated with a progressive reduction in physical quality of life among overweight middle-aged men.Scientific reports · 2014Trial
- Associations Between Both HIV and Metabolic Comorbidity and Self-Reported Mpox Among Men Who Have Sex With Men: Multicenter Cross-Sectional Study.JMIR public health and surveillance · 2025Article
- Ten Year Follow-Up After Explantation of the Duodenal-jejunal Bypass Liner.Obesity surgery · 2025Article
- Economic Evaluation of a Personalized Nutrition Plan Based on Omic Sciences Versus a General Nutrition Plan in Adults with Overweight and Obesity: A Modeling Study Based on Trial Data in Denmark.PharmacoEconomics - open · 2024Article
- Network Pharmacological Analysis of a New Herbal Combination Targeting Hyperlipidemia and Efficacy Validation In Vitro.Current issues in molecular biology · 2023Article
- Association of metabolic comorbidity with myocardial infarction in individuals with a family history of cardiovascular disease: a prospective cohort study.BMC public health · 2022Article
- The prototype of a preference-based index of weight-related quality of life: demonstrating the possibilities.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Morbid obesity, multiple long-term conditions, and health-related quality of life among Australian adults: Estimates from three waves of a longitudinal household survey.Preventive medicine reports · 2022Article
- Metabolic Phenotypes-The Game Changer in Quality of Life of Obese Patients?Healthcare (Basel, Switzerland) · 2022Article
- The association of body mass index with quality of life and working ability: a Finnish population-based study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Burden of disease study of overweight and obesity; the societal impact in terms of cost-of-illness and health-related quality of life.BMC public health · 2022Article
- Comorbidity and quality of life in obesity-a comparative study with the general population in Gothenburg, Sweden.PloS one · 2022Observational
- The association between obesity and quality of life: a retrospective analysis of a large-scale population-based cohort study.BMC public health · 2021Article
- Pregnancy weight gain may affect perinatal outcomes, quality of life during pregnancy, and child-bearing expenses: an observational cohort study.Archives of gynecology and obstetrics · 2021Observational
- Metabolic comorbidities and the association with risks of recurrent metastatic disease in breast cancer survivors.BMC cancer · 2021Article
- Association between metabolically healthy obesity/overweight and cardiovascular disease risk: A representative cohort study in Taiwan.PloS one · 2021Article
- Impact of prepregnancy body mass index on pregnancy outcomes, incidence of urinary incontinence and quality of life during pregnancy - An observational cohort study.Biomedical journal · 2020Observational
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4 authors.
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Abstract
backgroundThe prevalence of obesity is rising in Scotland and globally. Overall, obesity is associated with increased morbidity, mortality and reduced health-related quality of life. Studies suggest that "healthy obesity" (obesity without metabolic comorbidity) may not be associated with morbidity or mortality. Its impact on health-related quality of life is unknown.
methodsWe extracted data from the Scottish Health Survey on self-reported health-related quality of life, body mass index (BMI), demographic information and comorbidity. SF-12 responses were converted into an overall health utility score. Linear regression analyses were used to explore the association between BMI and health utility, stratified by the presence or absence of metabolic comorbidity (diabetes, hypertension, hypercholesterolemia or cardiovascular disease), and adjusted for potential confounders (age, sex and deprivation quintile).
resultsOf the 5,608 individuals, 3,744 (66.8%) were either overweight or obese and 921 (16.4%) had metabolic comorbidity. There was an inverted U-shaped relationship whereby health utility was highest among overweight individuals and fell with increasing BMI. There was a significant interaction with metabolic comorbidity (p = 0.007). Individuals with metabolic comorbidty had lower utility scores and a steeper decline in utility with increasing BMI (morbidly obese, adjusted coefficient: -0.064, 95% CI -0.115, -0.012, p = 0.015 for metabolic comorbidity versus -0.042, 95% CI -0.067, -0.018, p = 0.001 for no metabolic comorbidity).
conclusionsThe adverse impact of obesity on health-related quality of life is greater among individuals with metabolic comorbidity. However, increased BMI is associated with reduced health-related quality of life even in the absence of metabolic comorbidity, casting doubt on the notion of "healthy obesity".
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