ArticleBMC genetics2012
Genomic scan of selective sweeps in thin and fat tail sheep breeds for identifying of candidate regions associated with fat deposition.
Article in BMC genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 1 of them a synthesis that pooled it.
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127 citing papers in PubMed, 1 synthesis or guideline pooled it, 283 citations in OpenAlex.
- Insights into the influence of diet and genetics on feed efficiency and meat production in sheep.Animal genetics · 2024Pooled it
- Molecular Epidemiology of Peste des Petits Ruminants Virus Circulating in Fat-Tailed Sheep in Bangladesh.Veterinary medicine and science · 2026Article
- Unravelling the genetic structure and genetic relationships of indigenous Greek sheep breeds using SNP markers.Genetics, selection, evolution : GSE · 2026Article
- Effects of Summer Heat Stress on Physiological Parameters and Reproductive Efficiency of Barbarine Ewes Under Natural Outdoor or Indoor Conditions.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Identification of miR-320d as a Negative Regulator of Proliferation and Fatty Acid Synthesis via Targeting SCD in Ovine Tail Preadipocytes.Animals : an open access journal from MDPI · 2026Article
- Identification of Genomic Differences Resulting from Selection in Iranian Kurdish and Turkmen Horse Breeds Using Single Nucleotide Polymorphisms.Iranian journal of biotechnology · 2026Article
- Mitochondrial DNA variation reveals shared maternal lineages between Kazakh and Turkish fat-tailed sheep breeds.BMC veterinary research · 2026Article
- Comprehensive analysis of population structure and genomic diversity in fifteen Anatolian sheep breeds.BMC veterinary research · 2026Article
- The Influence of theAnimals : an open access journal from MDPI · 2026Article
- Artificial and natural selection components reveal the mechanisms of tropical sheep populations against gastrointestinal parasites.PloS one · 2026Article
- Decoding the Function ofAnimals : an open access journal from MDPI · 2025Article
- Genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations.Science China. Life sciences · 2025Review
- Integrated multiomic profiling of tail adipose tissue highlights novel genes, lipids, and metabolites involved in tail fat deposition in sheep.BMC genomics · 2025Article
- History and genetic diversity of African sheep: Contrasting phenotypic and genomic diversity.Animal genetics · 2025Review
- Genome-wide scans for signatures of selection in North African sheep reveals differentially selected regions between fat- and thin-tailed breeds.Animal genetics · 2025Article
- Genomic insights into runs of homozygosity, effective population size and selection signatures in Iranian meat and dairy sheep breeds.PloS one · 2025Article
- Genome-wide identification of selection signals in fat-tailed and thin-tailed sheep populations.Frontiers in genetics · 2025Article
- Whole-genome resequencing to investigate the genetic diversity and mechanisms of plateau adaptation in Tibetan sheep.Journal of animal science and biotechnology · 2024Article
- Article
- circARID1A Inhibits Tail Fat Cell Differentiation in Guangling Large-Tailed Sheep by Regulating the miR-493-3p/YTHDF2 Axis.International journal of molecular sciences · 2024Article
67 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdentification of genomic regions that have been targets of selection for phenotypic traits is one of the most important and challenging areas of research in animal genetics. However, currently there are relatively few genomic regions identified that have been subject to positive selection. In this study, a genome-wide scan using ~50,000 Single Nucleotide Polymorphisms (SNPs) was performed in an attempt to identify genomic regions associated with fat deposition in fat-tail breeds. This trait and its modification are very important in those countries grazing these breeds.
resultsTwo independent experiments using either Iranian or Ovine HapMap genotyping data contrasted thin and fat tail breeds. Population differentiation using FST in Iranian thin and fat tail breeds revealed seven genomic regions. Almost all of these regions overlapped with QTLs that had previously been identified as affecting fat and carcass yield traits in beef and dairy cattle. Study of selection sweep signatures using FST in thin and fat tail breeds sampled from the Ovine HapMap project confirmed three of these regions located on Chromosomes 5, 7 and X. We found increased homozygosity in these regions in favour of fat tail breeds on chromosome 5 and X and in favour of thin tail breeds on chromosome 7.
conclusionsIn this study, we were able to identify three novel regions associated with fat deposition in thin and fat tail sheep breeds. Two of these were associated with an increase of homozygosity in the fat tail breeds which would be consistent with selection for mutations affecting fat tail size several thousand years after domestication.
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