ArticleJournal of biomedical science2012
Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A.
Article in Journal of biomedical science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Preparation of bacoside A encapsulated PLGA-PEG nanoparticles for neuroprotection against kainic acid-induced excitotoxicity.Inflammopharmacology · 2026Article
- Anti-Inflammatory and Antioxidant Strategies in Epilepsy: From Molecular Mechanisms to Threshold Management.International journal of molecular sciences · 2026Review
- Executive Functioning and Language in a Pediatric Population with Autism Spectrum Disorders and Epilepsy: A Comparative Study.Children (Basel, Switzerland) · 2024Article
- InvestigatingCurrent pharmaceutical design · 2024Review
- Cognitive comorbidities in the rat pilocarpine model of epilepsy.Frontiers in neurology · 2024Article
- Receptor expression and signaling properties in the brain, and structural ligand motifs that contribute to delta opioid receptor agonist-induced seizures.Neuropharmacology · 2023Review
- The Promising Epigenetic Regulators for Refractory Epilepsy: An Adventurous Road Ahead.Neuromolecular medicine · 2023Review
- Review
- The Multifaceted Role of Neuroprotective Plants in Alzheimer's Disease Treatment.Geriatrics (Basel, Switzerland) · 2022Review
- Natural product-based pharmacological studies for neurological disorders.Frontiers in pharmacology · 2022Review
- Role of Standardized Plant Extracts in Controlling Alcohol Withdrawal Syndrome-An Experimental Study.Brain sciences · 2021Article
- Oligodendroglial GABAergic Signaling: More Than Inhibition!Neuroscience bulletin · 2021Review
- Neuroprotection with Bacopa monnieri-A review of experimental evidence.Molecular biology reports · 2021Review
- Food supplements based on palmitoylethanolamide plus hydroxytyrosol from olive tree or Bacopa monnieri extracts for neurological diseases.Acta bio-medica : Atenei Parmensis · 2020Review
- Phytochemicals for Improving Aspects of Cognitive Function and Psychological State Potentially Relevant to Sports Performance.Sports medicine (Auckland, N.Z.) · 2019Review
- Epilepsy and Autism Spectrum Disorder: An Epidemiological Study in Shanghai, China.Frontiers in psychiatry · 2019Article
- Effect of pre- and post-treatment withNeuropsychiatric disease and treatment · 2019Article
- Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I.Current neuropharmacology · 2019Review
- Epigenetic Suppression of GADs Expression is Involved in Temporal Lobe Epilepsy and Pilocarpine-Induced Mice Epilepsy.Neurochemical research · 2016Article
- A Special Extract of Bacopa monnieri (CDRI-08) Restores Learning and Memory by Upregulating Expression of the NMDA Receptor Subunit GluN2B in the Brain of Scopolamine-Induced Amnesic Mice.Evidence-based complementary and alternative medicine : eCAM · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGamma amino butyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tones that counter balances neuronal excitation. When this balance is perturbed, seizures may ensue.
methodsIn the present study, alterations of the general GABA, GABAA and GABAB receptors in the cerebral cortex of the epileptic rat and the therapeutic application of Bacopa monnieri were investigated.
resultsScatchard analysis of [3H]GABA, [3H]bicuculline and [3H]baclofen in the cerebral cortex of the epileptic rat showed significant decrease in Bmax (P < 0.001) compared to control. Real Time PCR amplification of GABA receptor subunits such as GABAAά1, GABAAγ, GABAAδ, GABAB and GAD where down regulated (P < 0.001) in epileptic rats. GABAAά5 subunit and Cyclic AMP responsible element binding protein were up regulated. Confocal imaging study confirmed the decreased GABA receptors in epileptic rats. Epileptic rats have deficit in radial arm and Y maze performance.
conclusionsBacopa monnieri and Bacoside-A treatment reverses epilepsy associated changes to near control suggesting that decreased GABA receptors in the cerebral cortex have an important role in epileptic occurrence; Bacopa monnieri and Bacoside-A have therapeutic application in epilepsy management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.