ArticlePLoS neglected tropical diseases2012
Clear genetic distinctiveness between human- and pig-derived Trichuris based on analyses of mitochondrial datasets.
Article in PLoS neglected tropical diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 143 citations in OpenAlex.
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- The complete mitochondrial genome of Wellcomia compar (Spirurina: Oxyuridae) and its genome characterization and phylogenetic analysis.Scientific reports · 2023Article
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- De novo assembled mitogenome analysis of Trichuris trichiura from Korean individuals using nanopore-based long-read sequencing technology.PLoS neglected tropical diseases · 2023Article
- Prevalences and Characteristics ofJournal of veterinary research · 2022Article
- Population genomics of ancient and modern Trichuris trichiura.Nature communications · 2022Article
- Inverted base composition skews and discontinuous mitochondrial genome architecture evolution in the Enoplea (Nematoda).BMC genomics · 2022Article
- The Use of MALDI-TOF MS as a Diagnostic Tool for AdultFrontiers in veterinary science · 2022Article
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- Nuclear and Mitochondrial Data onLife (Basel, Switzerland) · 2020Article
- Human gnathostomiasis: a neglected food-borne zoonosis.Parasites & vectors · 2020Review
- Trichuris trichiura isolated from Macaca sylvanus: morphological, biometrical, and molecular study.BMC veterinary research · 2020Article
- Article
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The whipworm, Trichuris trichiura, causes trichuriasis in ∼600 million people worldwide, mainly in developing countries. Whipworms also infect other animal hosts, including pigs (T. suis), dogs (T. vulpis) and non-human primates, and cause disease in these hosts, which is similar to trichuriasis of humans. Although Trichuris species are considered to be host specific, there has been considerable controversy, over the years, as to whether T. trichiura and T. suis are the same or distinct species. Here, we characterised the entire mitochondrial genomes of human-derived Trichuris and pig-derived Trichuris, compared them and then tested the hypothesis that the parasites from these two host species are genetically distinct in a phylogenetic analysis of the sequence data. Taken together, the findings support the proposal that T. trichiura and T. suis are separate species, consistent with previous data for nuclear ribosomal DNA. Using molecular analytical tools, employing genetic markers defined herein, future work should conduct large-scale studies to establish whether T. trichiura is found in pigs and T. suis in humans in endemic regions.
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