ArticlePloS one2012
Phosphine resistance in the rust red flour beetle, Tribolium castaneum (Coleoptera: Tenebrionidae): inheritance, gene interactions and fitness costs.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 157 citations in OpenAlex.
- Article
- Multiple mutations in Dihydrolipoamide dehydrogenase gene in phosphine resistant Rhyzopertha Dominica populations from India.Molecular biology reports · 2025Article
- Geographic Distribution of Phosphine Resistance and Frequency of Resistance Genes in Two Species of Grain Beetles,Insects · 2025Article
- Article
- Comparative Analysis of the Metabolic Profiles of Strains ofMolecules (Basel, Switzerland) · 2023Article
- Comparison of phenotypic and genotypic frequency of phosphine resistance in select field populations of Tribolium castaneum from India.Molecular biology reports · 2023Article
- Pesticidal Toxicity of Phosphine and Its Interaction with Other Pest Control Treatments.Current issues in molecular biology · 2023Review
- Detection of Phosphine Resistance in Field Populations of Four Key Stored-Grain Insect Pests in Pakistan.Insects · 2021Article
- Methyl Benzoate Is Superior to Other Natural Fumigants for Controlling the Indian Meal Moth (Insects · 2020Article
- Effect of Nitrogen on Phosphine-Susceptible and -Resistant Populations of Stored Product Insects.Insects · 2020Article
- Article
- The Molecular Mechanism of Aluminum Phosphide poisoning in Cardiovascular Disease: Pathophysiology and Diagnostic Approach.Cardiovascular toxicology · 2020Review
- Preliminary Study on the Differences in Hydrocarbons Between Phosphine-Susceptible and -Resistant Strains ofMolecules (Basel, Switzerland) · 2020Article
- Efficacy of Hypoxia Against Tribolium castaneum (Coleoptera: Tenebrionidae) Throughout Ontogeny.Journal of economic entomology · 2019Article
- The Desaturase Gene Family is Crucially Required for Fatty Acid Metabolism and Survival of the Brown Planthopper,International journal of molecular sciences · 2019Article
- Gene expression inPeerJ · 2019Article
- Variant Linkage Analysis UsingGenetics · 2018Article
- Progression of phosphine resistance in susceptibleEvolutionary applications · 2017Article
- Reference gene selection to determine differences in mitochondrial gene expressions in phosphine-susceptible and phosphine-resistant strains of Cryptolestes ferrugineus, using qRT-PCR.Scientific reports · 2017Article
- Gene Disruption Technologies Have the Potential to Transform Stored Product Insect Pest Control.Insects · 2016Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent emergence of heritable high level resistance to phosphine in stored grain pests is a serious concern among major grain growing countries around the world. Here we describe the genetics of phosphine resistance in the rust red flour beetle Tribolium castaneum (Herbst), a pest of stored grain as well as a genetic model organism. We investigated three field collected strains of T. castaneum viz., susceptible (QTC4), weakly resistant (QTC1012) and strongly resistant (QTC931) to phosphine. The dose-mortality responses of their test- and inter-cross progeny revealed that most resistance was conferred by a single major resistance gene in the weakly (3.2×) resistant strain. This gene was also found in the strongly resistant (431×) strain, together with a second major resistance gene and additional minor factors. The second major gene by itself confers only 12-20× resistance, suggesting that a strong synergistic epistatic interaction between the genes is responsible for the high level of resistance (431×) observed in the strongly resistant strain. Phosphine resistance is not sex linked and is inherited as an incompletely recessive, autosomal trait. The analysis of the phenotypic fitness response of a population derived from a single pair inter-strain cross between the susceptible and strongly resistant strains indicated the changes in the level of response in the strong resistance phenotype; however this effect was not consistent and apparently masked by the genetic background of the weakly resistant strain. The results from this work will inform phosphine resistance management strategies and provide a basis for the identification of the resistance genes.
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