ArticlePloS one2012
Sox10 controls migration of B16F10 melanoma cells through multiple regulatory target genes.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- SOX10, MITF, and microRNAs: Decoding their interplay in regulating melanoma plasticity.International journal of cancer · 2025Review
- Clinical Significance of SOX10 Expression in Human Pathology.Current issues in molecular biology · 2023Review
- DEPDC1B Promotes Melanoma Angiogenesis and Metastasis through Sequestration of Ubiquitin Ligase CDC16 to Stabilize Secreted SCUBE3.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Melanocortin 1 receptor is dispensable for acute stress induced hair graying in mice.Experimental dermatology · 2021Article
- Spherical Nucleic Acids for Topical Treatment of Hyperpigmentation.Journal of the American Chemical Society · 2021Article
- Sex-Determining Region Y Chromosome-Related High-Mobility-Group Box 10 in Cancer: A Potential Therapeutic Target.Frontiers in cell and developmental biology · 2020Review
- Depletion of WNT10A Prevents Tumor Growth by Suppressing Microvessels and Collagen Expression.International journal of medical sciences · 2019Article
- Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.Nature communications · 2018Article
- Critical in vivo roles of WNT10A in wound healing by regulating collagen expression/synthesis in WNT10A-deficient mice.PloS one · 2018Article
- Inhibition of melanocortin 1 receptor slows melanoma growth, reduces tumor heterogeneity and increases survival.Oncotarget · 2016Article
- Serpine2, a potential novel target for combating melanoma metastasis.American journal of translational research · 2016Article
- Regulation of SOX10 stability via ubiquitination-mediated degradation by Fbxw7α modulates melanoma cell migration.Oncotarget · 2015Article
- Muc1 promotes migration and lung metastasis of melanoma cells.American journal of cancer research · 2015Article
- Lipoteichoic acid isolated from Lactobacillus plantarum inhibits melanogenesis in B16F10 mouse melanoma cells.Molecules and cells · 2015Article
- Computational and in vitro Investigation of miRNA-Gene Regulations in Retinoblastoma Pathogenesis: miRNA Mimics Strategy.Bioinformatics and biology insights · 2015Article
- SOX10 promotes melanoma cell invasion by regulating melanoma inhibitory activity.The Journal of investigative dermatology · 2014Article
- Gene expression regulation by agonist-independent constitutive signaling of melanocortin-1 receptor.Endocrinology and metabolism (Seoul, Korea) · 2014Article
- Melanoma metastasis: new concepts and evolving paradigms.Oncogene · 2014Review
- Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling.Nature medicine · 2013Article
- The human melanoma side population displays molecular and functional characteristics of enriched chemoresistance and tumorigenesis.PloS one · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is believed that the inherent differentiation program of melanocytes during embryogenesis predisposes melanoma cells to high frequency of metastasis. Sox10, a transcription factor expressed in neural crest stem cells and a subset of progeny lineages, plays a key role in the development of melanocytes. We show that B16F10 melanoma cells transfected with siRNAs specific for Sox10 display reduced migratory activity which in turn indicated that a subset of transcriptional regulatory target genes of Sox10 is likely to be involved in migration and metastasis of melanoma cells. We carried out a microarray-based gene expression profiling using a Sox10-specific siRNA to identify relevant regulatory targets and found that multiple genes including melanocortin-1 receptor (Mc1r) partake in the regulation of migration. We provide evidences that the effect of Sox10 on migration is mediated in large part by Mitf, a transcription factor downstream to Sox10. Among the mouse melanoma cell lines examined, however, only B16F10 showed robust down-regulation of Sox10 and inhibition of cell migration indicating that further dissection of dosage effects and/or cell line-specific regulatory networks is necessary. The involvement of Mc1r in migration was studied in detail in vivo using a murine metastasis model. Specifically, B16F10 melanoma cells treated with a specific siRNA showed reduced tendency in metastasizing to and colonizing the lung after being injected in the tail vein. These data reveal a cadre of novel regulators and mediators involved in migration and metastasis of melanoma cells that represents potential targets of therapeutic intervention.
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