ArticlePloS one2012
Asymmetric stochastic switching driven by intrinsic molecular noise.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- A mathematical kinetic model of memory iniScience · 2026Article
- The Interplay Between Non-Instantaneous Dynamics of mRNA and Bounded Extrinsic Stochastic Perturbations for a Self-Enhancing Transcription Factor.Entropy (Basel, Switzerland) · 2026Article
- MaxCal can infer models from coupled stochastic trajectories of gene expression and cell division.Biophysical journal · 2023Article
- Terminal heterocyst differentiation in the Anabaena patA mutant as a result of post-transcriptional modifications and molecular leakage.PLoS computational biology · 2022Article
- Tunable phenotypic variability through an autoregulatory alternative sigma factor circuit.Molecular systems biology · 2021Article
- Bivalent chromatin as a therapeutic target in cancer: An in silico predictive approach for combining epigenetic drugs.PLoS computational biology · 2021Article
- Critical Comparison of MaxCal and Other Stochastic Modeling Approaches in Analysis of Gene Networks.Entropy (Basel, Switzerland) · 2021Article
- Switching behaviour in vascular smooth muscle cell-matrix adhesion during oscillatory loading.Journal of theoretical biology · 2020Article
- Unravelling the γ-butyrolactone network in Streptomyces coelicolor by computational ensemble modelling.PLoS computational biology · 2020Article
- The Maximum Caliber Variational Principle for Nonequilibria.Annual review of physical chemistry · 2020Review
- Improvement of the memory function of a mutual repression network in a stochastic environment by negative autoregulation.BMC bioinformatics · 2019Article
- Maximum Caliber Can Build and Infer Models of Oscillation in a Three-Gene Feedback Network.The journal of physical chemistry. B · 2019Article
- Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors.Cell systems · 2018Article
- Role of noise and parametric variation in the dynamics of gene regulatory circuits.NPJ systems biology and applications · 2018Article
- Building Predictive Models of Genetic Circuits Using the Principle of Maximum Caliber.Biophysical journal · 2017Article
- Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in theeLife · 2017Article
- Intrinsic Noise Profoundly Alters the Dynamics and Steady State of Morphogen-Controlled Bistable Genetic Switches.PLoS computational biology · 2016Article
- Stochastic modeling suggests that noise reduces differentiation efficiency by inducing a heterogeneous drug response in glioma differentiation therapy.BMC systems biology · 2016Article
- Gene switching rate determines response to extrinsic perturbations in the self-activation transcriptional network motif.Scientific reports · 2016Article
- The cellular Ising model: a framework for phase transitions in multicellular environments.Journal of the Royal Society, Interface · 2016Article
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4 authors.
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Abstract
Low-copy-number molecules are involved in many functions in cells. The intrinsic fluctuations of these numbers can enable stochastic switching between multiple steady states, inducing phenotypic variability. Herein we present a theoretical and computational study based on Master Equations and Fokker-Planck and Langevin descriptions of stochastic switching for a genetic circuit of autoactivation. We show that in this circuit the intrinsic fluctuations arising from low-copy numbers, which are inherently state-dependent, drive asymmetric switching. These theoretical results are consistent with experimental data that have been reported for the bistable system of the gallactose signaling network in yeast. Our study unravels that intrinsic fluctuations, while not required to describe bistability, are fundamental to understand stochastic switching and the dynamical relative stability of multiple states.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.