ArticlePloS one2012
A novel framework for the comparative analysis of biological networks.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- L-HetNetAligner: A novel algorithm for Local Alignment of Heterogeneous Biological Networks.Scientific reports · 2020Article
- A genome-scale metabolic network alignment method within a hypergraph-based framework using a rotational tensor-vector product.Scientific reports · 2018Article
- INTERSPIA: a web application for exploring the dynamics of protein-protein interactions among multiple species.Nucleic acids research · 2018Article
- Genetic tests in major psychiatric disorders-integrating molecular medicine with clinical psychiatry-why is it so difficult?Translational psychiatry · 2017Review
- Local versus global biological network alignment.Bioinformatics (Oxford, England) · 2016Article
- The post-genomic era of biological network alignment.EURASIP journal on bioinformatics & systems biology · 2015Article
- GreedyPlus: An Algorithm for the Alignment of Interface Interaction Networks.Scientific reports · 2015Article
- Fair evaluation of global network aligners.Algorithms for molecular biology : AMB · 2015Article
- A second-generation protein-protein interaction network of Helicobacter pylori.Molecular & cellular proteomics : MCP · 2014Article
- Increasing the precision of orthology-based complex prediction through network alignment.PeerJ · 2014Article
- Gene regulatory networks and their applications: understanding biological and medical problems in terms of networks.Frontiers in cell and developmental biology · 2014Review
- Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review.Pharmacology & therapeutics · 2013Review
- NetAligner--a network alignment server to compare complexes, pathways and whole interactomes.Nucleic acids research · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome sequencing projects provide nearly complete lists of the individual components present in an organism, but reveal little about how they work together. Follow-up initiatives have deciphered thousands of dynamic and context-dependent interrelationships between gene products that need to be analyzed with novel bioinformatics approaches able to capture their complex emerging properties. Here, we present a novel framework for the alignment and comparative analysis of biological networks of arbitrary topology. Our strategy includes the prediction of likely conserved interactions, based on evolutionary distances, to counter the high number of missing interactions in the current interactome networks, and a fast assessment of the statistical significance of individual alignment solutions, which vastly increases its performance with respect to existing tools. Finally, we illustrate the biological significance of the results through the identification of novel complex components and potential cases of cross-talk between pathways and alternative signaling routes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.