ArticlePloS one2012
Yersinia pestis lineages in Mongolia.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A field-deployable high-resolution SNP genotyping platform for rapid surveillance ofVirulence · 2026Article
- Plagued by the Past, Pressed by the Present: A One Health Perspective onBiomedicines · 2025Review
- MAJOR LIVESTOCK-ASSOCIATED ZOONOSES IN MONGOLIA: AN OVERVIEW.Zoonoses (Shannon, Ireland) · 2025Article
- Parallelism in Speciation and Intraspecific Diversification of the Plague MicrobeBiology bulletin of the Russian Academy of Sciences · 2023Article
- Distribution and Characteristics of Human Plague Cases and Yersinia pestis Isolates from 4 Marmota Plague Foci, China, 1950-2019.Emerging infectious diseases · 2021Review
- Biological activity evaluations of chemical constituents derived from Mongolian medicinal forage plants and their applications in combating infectious diseases and addressing health problems in humans and livestock.Journal of natural medicines · 2021Review
- Yersinia pestis: the Natural History of Plague.Clinical microbiology reviews · 2020Review
- Historical and genomic data reveal the influencing factors on global transmission velocity of plague during the Third Pandemic.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Ten years of surveillance of the Yulong plague focus in China and the molecular typing and source tracing of the isolates.PLoS neglected tropical diseases · 2018Article
- Genotypic Expansion Within the Population Structure of ClassicalFrontiers in microbiology · 2018Article
- Reemergence of human plague in Yunnan, China in 2016.PloS one · 2018Article
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- Russian isolates enlarge the known geographic diversity of Francisella tularensis subsp. mediasiatica.PloS one · 2017Article
- How old are bacterial pathogens?Proceedings. Biological sciences · 2016Review
- Whole genome multilocus sequence typing as an epidemiologic tool for Yersinia pestis.Diagnostic microbiology and infectious disease · 2016Article
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- Article
- Nineteen Whole-Genome Assemblies of Yersinia pestis subsp. microtus, Including Representatives of Biovars caucasica, talassica, hissarica, altaica, xilingolensis, and ulegeica.Genome announcements · 2015Article
- Diverse Genotypes of Yersinia pestis Caused Plague in Madagascar in 2007.PLoS neglected tropical diseases · 2015Article
- Pneumonic plague outbreak, Northern Madagascar, 2011.Emerging infectious diseases · 2015Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhole genome sequencing allowed the development of a number of high resolution sequence based typing tools for Yersinia (Y.) pestis. The application of these methods on isolates from most known foci worldwide and in particular from China and the Former Soviet Union has dramatically improved our understanding of the population structure of this species. In the current view, Y. pestis including the non or moderate human pathogen Y. pestis subspecies microtus emerged from Yersinia pseudotuberculosis about 2,600 to 28,600 years ago in central Asia. The majority of central Asia natural foci have been investigated. However these investigations included only few strains from Mongolia. METHODOLOGY/PRINCIPAL
findingsClustered Regularly Interspaced Short Prokaryotic Repeats (CRISPR) analysis and Multiple-locus variable number of tandem repeats (VNTR) analysis (MLVA) with 25 loci was performed on 100 Y. pestis strains, isolated from 37 sampling areas in Mongolia. The resulting data were compared with previously published data from more than 500 plague strains, 130 of which had also been previously genotyped by single nucleotide polymorphism (SNP) analysis. The comparison revealed six main clusters including the three microtus biovars Ulegeica, Altaica, and Xilingolensis. The largest cluster comprises 78 isolates, with unique and new genotypes seen so far in Mongolia only. Typing of selected isolates by key SNPs was used to robustly assign the corresponding clusters to previously defined SNP branches. CONCLUSIONS/SIGNIFICANCE: We show that Mongolia hosts the most recent microtus clade (Ulegeica). Interestingly no representatives of the ancestral Y. pestis subspecies pestis nodes previously identified in North-western China were identified in this study. This observation suggests that the subsequent evolution steps within Y. pestis pestis did not occur in Mongolia. Rather, Mongolia was most likely re-colonized by more recent clades coming back from China contemporary of the black death pandemic, or more recently in the past 600 years.
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