ArticlePloS one2012
Hospital and community ampicillin-resistant Enterococcus faecium are evolutionarily closely linked but have diversified through niche adaptation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Comparative study on the time trends of antimicrobial resistance at animal and human hospitals in a shared community.One health (Amsterdam, Netherlands) · 2025Article
- VirulenceFinder forMicrobiology spectrum · 2024Article
- Ampicillin-susceptibleMicrobiology spectrum · 2023Article
- Top-Down Genomic Surveillance Approach To Investigate the Genomic Epidemiology and Antibiotic Resistance Patterns of Enterococcus faecium Detected in Cancer Patients in Arkansas.Microbiology spectrum · 2023Article
- Strengthening of enterococcal biofilms by Esp.PLoS pathogens · 2022Article
- Natural Photosensitizers in Antimicrobial Photodynamic Therapy.Biomedicines · 2021Review
- New Insights into the Virulence Traits and Antibiotic Resistance of Enterococci Isolated from Diverse Probiotic Products.Microorganisms · 2021Article
- Complexities in understanding antimicrobial resistance across domesticated animal, human, and environmental systems.Annals of the New York Academy of Sciences · 2019Review
- Detection of vancomycin-resistantGenome research · 2019Article
- Antimicrobial Resistance inMicrobiology spectrum · 2018Review
- RNA-seq and Tn-seq reveal fitness determinants of vancomycin-resistant Enterococcus faecium during growth in human serum.BMC genomics · 2017Article
- Characterization ofFrontiers in microbiology · 2017Article
- Genomic Features and Niche-Adaptation of Enterococcus faecium Strains from Korean Soybean-Fermented Foods.PloS one · 2016Article
- Co-diversification ofFrontiers in microbiology · 2016Article
- Distinct SagA from Hospital-Associated Clade A1 Enterococcus faecium Strains Contributes to Biofilm Formation.Applied and environmental microbiology · 2015Article
- Population biology of intestinal enterococcus isolates from hospitalized and nonhospitalized individuals in different age groups.Applied and environmental microbiology · 2015Article
- Genome sequences of copper resistant and sensitive Enterococcus faecalis strains isolated from copper-fed pigs in Denmark.Standards in genomic sciences · 2015Article
- Enterococci and Their Interactions with the Intestinal Microbiome.Microbiology spectrum · 2014Article
- Safety of the surrogate microorganism Enterococcus faecium NRRL B-2354 for use in thermal process validation.Applied and environmental microbiology · 2014Article
- Nonclinical and clinical Enterococcus faecium strains, but not Enterococcus faecalis strains, have distinct structural and functional genomic features.Applied and environmental microbiology · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmpicillin-resistant Enterococcus faecium (ARE) has emerged as a nosocomial pathogen. Here, we quantified ARE carriage in different community sources and determined genetic relatedness with hospital ARE. METHODS AND
resultsARE was recovered from rectal swabs of 24 of 79 (30%) dogs, 11 of 85 (13%) cats and 0 of 42 horses and from 3 of 40 (8%) faecal samples of non-hospitalized humans receiving amoxicillin. Multi-locus Sequence Typing revealed 21 sequence types (STs), including 5 STs frequently associated with hospital-acquired infections. Genes previously found to be enriched in hospital ARE, such as IS16, orf903, orf905, orf907, were highly prevalent in community ARE (≥79%), while genes with a proposed role in pathogenesis, such as esp, hyl and ecbA, were found rarely (≤5%) in community isolates. Comparative genome analysis of 2 representative dog isolates revealed that the dog strain of ST192 was evolutionarily closely linked to two previously sequenced hospital ARE, but had, based on gene content, more genes in common with the other, evolutionarily more distantly related, dog strain (ST266).
conclusionARE were detected in dogs, cats and sporadically in healthy humans, with evolutionary linkage to hospital ARE. Yet, their accessory genome has diversified, probably as a result of niche adaptation.
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