ArticleDental research journal2012
Clinical and radiographic evaluation of Nano-crystalline hydroxyapatite bone graft (Sybograf) in combination with bioresorbable collagen membrane (Periocol) in periodontal intrabony defects.
Article in Dental research journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Comparing Nanohydroxyapatite Graft and Other Bone Grafts in the Repair of Periodontal Infrabony Lesions: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2021Pooled it
- Histologic and Histomorphometric Comparison between Sintered Nanohydroxyapatite and Anorganic Bovine Xenograft in Maxillary Sinus Grafting: A Split-Mouth Randomized Controlled Clinical Trial.BioMed research international · 2017Trial
- Clinical outcomes after treatment of periodontal intrabony defects with nanocrystalline hydroxyapatite (Ostim) or enamel matrix derivatives (Emdogain): a randomized controlled clinical trial.BioMed research international · 2014Trial
- How Will Nanomedicine Revolutionize Future Dentistry and Periodontal Therapy?International journal of molecular sciences · 2025Review
- Periapical healing in endodontic retreatment: A comparative study of nano-hydroxyapatite with and without PRF.Bioinformation · 2025Article
- Nanocrystalline hydroxyapatite in periodontal bone regeneration: A systematic review.The Saudi dental journal · 2022Review
- Effect of Injectable Platelet-Rich Fibrin with a Nano-Hydroxyapatite Bone Graft on the Treatment of a Grade II Furcation Defect.Bioengineering (Basel, Switzerland) · 2022Article
- Metformin-Incorporated Gelatin/Nano-Hydroxyapatite Scaffolds Promotes Bone Regeneration in Critical Size Rat Alveolar Bone Defect Model.International journal of molecular sciences · 2022Article
- Article
- Nano-hydroxyapatite and its applications in preventive, restorative and regenerative dentistry: a review of literature.Annali di stomatologia · 2014Article
- Treatment strategy for guided tissue regeneration in various class II furcation defect: Case series.Dental research journal · 2013Article
- Clinicoradiographic evaluation of advanced-platelet rich fibrin block (A PRF + i PRF + nanohydroxyapatite) compared to nanohydroxyapatite alone in the management of periodontal intrabony defects.Journal of Indian Society of PeriodontologyArticle
- Clinical and radiographic evaluation of nanocrystalline hydroxyapatite with or without platelet-rich fibrin membrane in the treatment of periodontal intrabony defects.Journal of Indian Society of PeriodontologyArticle
- Two dimensional alveolar ridge augmentation using particulate hydroxyapatite and collagen membrane: A case report.Journal of oral biology and craniofacial researchArticle
- Comparative evaluation of the efficacy of synthetic nanocrystalline hydroxyapatite bone graft (OstimJournal of Indian Society of PeriodontologyArticle
- Treatment of horizontal defect with and without platelet-rich fibrin matrix: A randomized comparative clinical study.Journal of Indian Society of PeriodontologyArticle
- Combined endodontic therapy and peri-radicular regenerative surgery in the treatment of dens invaginatus type III associated with apicomarginal defect.Journal of conservative dentistry : JCDArticle
- Bioactive glass versus autologous platelet-rich fibrin for treating periodontal intrabony defects: A comparative clinical study.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNanosized ceramics may represent a promising class of bone graft substitutes due to their improved osseointegrative properties. Nanocrystalline Hydroxyapatite (NcHA) bind to bone and stimulate bone healing by stimulation of osteoblast activity. The present study aims to explore the clinical and radiographical outcome of NcHA bonegraft (Sybograf(®)) with collagen membrane (Periocol(®)), in comparison with open flap debridement (OFD), in the treatment of intrabony periodontal defects. MATERIALS AND
methodsA parallel-group, randomized, controlled clinical trial was designed to conduct the study. Eighteen intrabony defects in 14 systemically healthy patients aged between 25 to 65 years were randomly assigned to test and control group. The plaque index, gingival index, probing pocket depth (PPD), clinical attachment level (CAL), and gingival recession (REC) were recorded at baseline, and were reevaluated at 6 months. In addition to this, radiographic bone fill was assessed using digital software. At the test site, NcHA bone graft and collagen membrane was placed, whereas at the control site, only OFD was done. Recall appointments were made at 7 days, 30 days, and then at 3 months and 6 months.
resultsThe data were subjected to statistical analysis using the Mann-Whitney 'U' Test and Wilcoxon signed rank sum test. In the control group, the mean reduction of PPD was 3.22±1.09 mm (P=0.007) and CAL gain was 2.77±1.09 mm (P=0.007). In the test group, the mean PPD reduction of 4.33±0.5 mm (P=0.006) and mean gain in CAL was 3.77±0.66 mm (P=0.006) at 6 months. The mean increase in REC was 0.55±0.72 mm (P=0.025) in test, and 0.44±0.52 mm (P=0.046) in control group. The mean gain in radiographic defect fill was 2.07±0.67 mm (P=0.008) in test and 0.91±0.21 mm (P=0.007) in control group.
conclusionThe nanocrystalline hydroxyapatite bone graft in combination with collagen membrane demonstrated clinical advantages beyond that achieved by OFD alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.