ArticleDental research journal2012
Comparative immunohistochemical analysis of angiogenesis and mast cell density in oral normal mucosa and squamous cell carcinoma.
Article in Dental research journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Evaluation of Tumor-Associated Macrophages and Micro-Vessel Density in Verrucous Carcinoma and Squamous Cell Carcinoma of the Oral Cavity.Advanced biomedical research · 2024Article
- Correlation of Mast Cell and Angiogenesis in Oral Lichen Planus, Dysplasia (Leukoplakia), and Oral Squamous Cell Carcinoma.Rambam Maimonides medical journal · 2021Article
- Mast Cells and Blood Vessels Profile in Oral Carcinogenesis: An Immunohistochemistry Study.Asian Pacific journal of cancer prevention : APJCP · 2020Observational
- The role of mast cells in oral squamous cell carcinoma.Contemporary oncology (Poznan, Poland) · 2017Review
- Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity.BioMed research international · 2016Review
- Cd34 and Mast Cell Analysis in Normal Oral Mucosa and Different Grades of Oral Squamous Cell Carcinoma: A Comparative Study.Journal of clinical and diagnostic research : JCDR · 2015Article
- Serum lipid profile in patients with oral cancer and oral precancerous conditions.Dental research journal · 2014Article
- Mast cell count in oral reactive lesions: A histochemical study.Dental research journal · 2014Article
- A histochemical study of tissue eosinophilia in oral squamous cell carcinoma using Congo red staining.Dental research journal · 2013Article
- A comparative study of histological grade and expression of Ki67 protein in oral squamous cell carcinoma in young and old patients.Dental research journal · 2013Article
- CD34 Angiogenesis Marker in Oral Squamous Cell Carcinoma: An Immunohistochemical Study.Contemporary clinical dentistryArticle
- Mast cells and oral pathologies: A Review.Journal of natural science, biology, and medicineReview
- Detection of Candida albicans in oral squamous cell carcinoma by fluorescence staining technique.Dental research journalArticle
- Immunohistochemical analysis of angiogenesis by CD34 and mast cells by toluidine blue in different grades of oral squamous cell carcinoma.Journal of oral and maxillofacial pathology : JOMFPArticle
- To evaluate the role of mast cells on angiogenesis in various grades of oral squamous cell carcinoma: A histochemical study.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSquamous cell carcinoma (SCC) is the most common malignancy in oral cavity. Angiogenesis is essential for the development and progression of SCC. Recently, some studies have reported that mast cells may play a role in tumor progression via promoting angiognesis. Since the results of various studies on the role of mast cells in tumor progression is not uniform, the aim of this study was to define the possible role of mast cells in the process of angiogenesis by determining the microvessel density (MVD) and mast cell density (MCD) and the association between them in oral normal mucsoa and oral SCC. MATERIALS AND
methodsIn this retrospective analytical study, paraffinized specimens from 22 cases of normal mucosa and 20 cases of well-differentiated oral SCC were selected. Microvessels were stained by using immunohistochemical technique with anti-CD34 antibody and mast cells with toluidine blue and then were counted at 400× magnification in hot-spot areas under a light microscope. The results were analyzed by using t- test and Pearson's exams. P values less than 0.05 was considered to be significant.
resultsA significant correlation was noted between MVD and MCD in normal oral mucosa (P<0.001), but in spite of a higher density of mast cells and microvessels observed in oral SCC compared to normal mucosa, there was no significant correlation between them (P=0.731).
conclusionThese findings showed that factors other than mast cells may play a role in the upregulation of tumor angiogenesis in oral SCC.
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