ArticleFrontiers in physiology2012
Remote ischemic conditioning: from bench to bedside.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03899532 (The Effect of Remote Ischemic Conditioning), which is not on this map. Cited by 77 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Remote Ischemic Conditioning (RIC) on Inflammatory Biomarkers and Outcomes in Patients With TBI
Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 171 citations in OpenAlex.
- Remote ischaemic conditioning for preventing and treating ischaemic stroke.The Cochrane database of systematic reviews · 2025Pooled it
- Remote ischaemic conditioning for preventing and treating ischaemic stroke.The Cochrane database of systematic reviews · 2018Pooled it
- Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review.Arquivos brasileiros de cardiologia · 2015Pooled it
- Remote ischemic post-conditioning for neonatal encephalopathy: a safety and feasibility trial.Pediatric research · 2025Trial
- Effect of remote ischaemic conditioning on platelet reactivity and endogenous fibrinolysis in ST-elevation myocardial infarction: a substudy of the CONDI-2/ERIC-PPCI randomized controlled trial.Cardiovascular research · 2021Trial
- Apoptosis-related microRNA changes in the right atrium induced by remote ischemic perconditioning during valve replacement surgery.Scientific reports · 2016Trial
- The effect of remote ischemic preconditioning on upper extremity strength in healthy male adults: an updated systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2026Article
- Remote ischemic per-conditioning did not modulate kidney Klotho expression in acute kidney injury induced by renal ischemia/reperfusion injury.BMC nephrology · 2025Article
- Remote ischaemic post conditioning in NE: A feasible and simple paradigm for self-protection in the brain?Pediatric research · 2025Article
- Promoting Resiliency to Stress in the Vascular Endothelium.Basic & clinical pharmacology & toxicology · 2025Review
- Ischemic Preconditioning Negatively Affects Thrombogenic Clotting Profile in Cerebral Small Vessel Occlusion Stroke Patients.Journal of clinical medicine research · 2025Article
- Effects of ischemic pre-conditioning on electrically stimulated contractions.European journal of applied physiology · 2025Article
- Multi-Target and Multi-Phase Adjunctive Cerebral Protection for Acute Ischemic Stroke in the Reperfusion Era.Biomolecules · 2024Review
- Biological resilience in health and disease.Disease models & mechanisms · 2024Review
- VRAC channel inhibition as a novel strategy for the treatment of ischemia-reperfusion injury.Frontiers in cell and developmental biology · 2024Review
- Acute remote ischemic conditioning enhances (CD3+)- but not (FoxP3+)-T-cell invasion in the tumor center and increases IL 17 and TNF-alpha expression in a murine melanoma model.Frontiers in immunology · 2024Article
- Article
- Article
- Potential Benefits of a Single Session of Remote Ischemic Preconditioning and Walking in Sedentary Older Adults: A Pilot Study.International journal of environmental research and public health · 2023Article
- Safety and efficacy of remote ischemic conditioning in adult moyamoya disease patients undergoing revascularization surgery: a pilot study.Frontiers in neurology · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury (IRI). It describes an endogenous phenomenon in which the application of one or more brief cycles of non-lethal ischemia and reperfusion to an organ or tissue protects a remote organ or tissue from a sustained episode of lethal IRI. Although RIC protection was first demonstrated to protect the heart against acute myocardial infarction, its beneficial effects are also seen in other organs (lung, liver, kidney, intestine, brain) and tissues (skeletal muscle) subjected to acute IRI. The recent discovery that RIC can be induced non-invasively by simply inflating and deflating a standard blood pressure cuff placed on the upper arm or leg, has facilitated its translation into the clinical setting, where it has been reported to be beneficial in a variety of cardiac scenarios. In this review article we provide an overview of RIC, the potential underlying mechanisms, and its potential as a novel therapeutic strategy for protecting the heart and other organs from acute IRI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.