ArticleFrontiers in neuroanatomy2012
The genesis of cerebellar GABAergic neurons: fate potential and specification mechanisms.
Article in Frontiers in neuroanatomy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- The Nuclear Transitory Zone: A Key Player in the Cerebellar Development.Cerebellum (London, England) · 2025Review
- The Hippo effector TEAD1 regulates postnatal murine cerebellar development.Brain structure & function · 2025Article
- Revisiting the development of cerebellar inhibitory interneurons in the light of single-cell genetic analyses.Histochemistry and cell biology · 2024Review
- Regulation of cerebellar network development by granule cells and their molecules.Frontiers in molecular neuroscience · 2023Review
- Early Cerebellar Development in Relation to the Trigeminal System.Cerebellum (London, England) · 2022Review
- Human Cerebellar Development and Transcriptomics: Implications for Neurodevelopmental Disorders.Annual review of neuroscience · 2022Review
- Morphological pseudotime ordering and fate mapping reveal diversification of cerebellar inhibitory interneurons.Nature communications · 2022Article
- Combining low-density cell culture, single-cell tracking, and patch-clamp to monitor the behavior of postnatal murine cerebellar neural stem cells.STAR protocols · 2021Article
- Cell Type-specific Knockout withExperimental neurobiology · 2021Article
- Article
- In Search of Molecular Markers for Cerebellar Neurons.International journal of molecular sciences · 2021Review
- Live Imaging Reveals Cerebellar Neural Stem Cell Dynamics and the Role of VNUT in Lineage Progression.Stem cell reports · 2020Article
- Diverse Neuron Properties and Complex Network Dynamics in the Cerebellar Cortical Inhibitory Circuit.Frontiers in molecular neuroscience · 2019Article
- An Animal Model for Assessing the Effects of Hydroxyurea Exposure Suggests That the Administration of This Agent to Pregnant Women and Young Infants May Not Be as Safe as We Thought.International journal of molecular sciences · 2018Review
- Moving into shape: cell migration during the development and histogenesis of the cerebellum.Histochemistry and cell biology · 2018Review
- Conditional deletion of Cadherin 13 perturbs Golgi cells and disrupts social and cognitive behaviors.Genes, brain, and behavior · 2018Article
- Embryology.Handbook of clinical neurology · 2018Review
- Effects of Hydroxyurea Exposure on the Rat Cerebellar Neuroepithelium: an Immunohistochemical and Electron Microscopic Study Along the Anteroposterior and Mediolateral Axes.Neurotoxicity research · 2017Article
- Developmental Injury to the Cerebellar Cortex Following Hydroxyurea Treatment in Early Postnatal Life: An Immunohistochemical and Electron Microscopic Study.Neurotoxicity research · 2017Article
- Consensus Paper: Cerebellar Development.Cerebellum (London, England) · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
all cerebellar neurons derive from progenitors that proliferate in two germinal neuroepitheliathe ventricular zone (VZ) generates GABAergic neurons, whereas the rhombic lip is the origin of glutamatergic types. Among VZ-derivatives, GABAergic projection neurons, and interneurons are generated according to distinct strategies. Projection neurons (Purkinje cells and nucleo-olivary neurons) are produced at the onset of cerebellar neurogenesis by discrete progenitor pools located in distinct VZ microdomains. These cells are specified within the VZ and acquire mature phenotypes according to cell-autonomous developmental programs. On the other hand, the different categories of inhibitory interneurons derive from a single population of Pax-2-positive precursors that delaminate into the prospective white matter (PWM), where they continue to divide up to postnatal development. Heterotopic/heterochronic transplantation experiments indicate that interneuron progenitors maintain full developmental potentialities up to the end of cerebellar development and acquire mature phenotypes under the influence of environmental cues present in the PWM. Furthermore, the final fate choice occurs in postmitotic cells, rather than dividing progenitors. Extracerebellar cells grafted to the prospective cerebellar white matter are not responsive to local neurogenic cues and fail to adopt clear cerebellar identities. Conversely, cerebellar cells grafted to extracerebellar regions retain typical phenotypes of cerebellar GABAergic interneurons, but acquire type-specific traits under the influence of local cues. These findings indicate that interneuron progenitors are multipotent and sensitive to spatio-temporally patterned environmental signals that regulate the genesis of different categories of interneurons, in precise quantities and at defined times and places.
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