ArticleFrontiers in neuroscience2012
New Neurons in Aging Brains: Molecular Control by Small Non-Coding RNAs.
Article in Frontiers in neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 67 citations in OpenAlex.
- Targeting neuroplasticity in old brain: restoring synapse with cognitive strategies.Biogerontology · 2026Review
- A Mild Dose of Aspirin Promotes Hippocampal Neurogenesis and Working Memory in Experimental Ageing Mice.Brain sciences · 2023Article
- Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression.Aging and disease · 2022Article
- Identification and functional characterization of CD133Molecular and cellular biochemistry · 2022Article
- Adult Neural Stem Cell Regulation by Small Non-coding RNAs: Physiological Significance and Pathological Implications.Frontiers in cellular neuroscience · 2021Article
- Tissue Engineering and Biomaterial Strategies to Elicit Endogenous Neuronal Replacement in the Brain.Frontiers in neurology · 2020Review
- miR-138 Increases Depressive-Like Behaviors by Targeting SIRT1 in Hippocampus.Neuropsychiatric disease and treatment · 2020Article
- Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.Scientific reports · 2019Article
- The orphan nuclear receptor TLX: an emerging master regulator of cross-talk between microglia and neural precursor cells.Neuronal signaling · 2019Article
- A role for the orphan nuclear receptor TLX in the interaction between neural precursor cells and microglia.Neuronal signaling · 2019Article
- Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures.Frontiers in molecular neuroscience · 2019Article
- Differential effects of chronic stress in young-adult and old female mice: cognitive-behavioral manifestations and neurobiological correlates.Molecular psychiatry · 2018Article
- Potential Roles of microRNAs in the Regulation of Monoamine Oxidase A in the Brain.Frontiers in molecular neuroscience · 2018Review
- miRNA-Mediated Regulation of Adult Hippocampal Neurogenesis; Implications for Epilepsy.Brain plasticity (Amsterdam, Netherlands) · 2017Review
- Synergic Functions of miRNAs Determine Neuronal Fate of Adult Neural Stem Cells.Stem cell reports · 2017Article
- Adult neurogenesis and neurodegenerative diseases: A systems biology perspective.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Article
- Exercise protects against methamphetamine-induced aberrant neurogenesis.Scientific reports · 2016Article
- Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons.Science (New York, N.Y.) · 2016Article
- The Cosmic Zoo: The (Near) Inevitability of the Evolution of Complex, Macroscopic Life.Life (Basel, Switzerland) · 2016Article
- Preserved neurogenesis in non-demented individuals with AD neuropathology.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult neurogenesis generates functional neurons from neural stem cells present in specific brain regions. It is largely confined to two main regions: the subventricular zone of the lateral ventricle, and the subgranular zone of the dentate gyrus (DG), in the hippocampus. With age, the function of the hippocampus and particularly the DG is impaired. For instance, adult neurogenesis is decreased with aging, in both proliferating and differentiation of newborn cells, while in parallel an age-associated decline in cognitive performance is often seen. Surprisingly, the synaptogenic potential of adult-born neurons is only marginally influenced by aging. Therefore, although proliferation, differentiation, and synaptogenesis of adult-born new neurons in the DG are closely related to each other, they are differentially affected by aging. In this review we discuss the crucial roles of a novel class of recently discovered modulators of gene expression, the small non-coding RNAs, in the regulation of adult neurogenesis. Multiple small non-coding RNAs are differentially expressed in the hippocampus. In particular a subgroup of the small non-coding RNAs, the microRNAs, fine-tune the progression of adult neurogenesis. This makes small non-coding RNAs appealing candidates to orchestrate the functional alterations in adult neurogenesis and cognition associated with aging. Finally, we summarize observations that link changes in circulating levels of steroid hormones with alterations in adult neurogenesis, cognitive decline, and vulnerability to psychopathology in advanced age, and discuss a potential interplay between steroid hormone receptors and microRNAs in cognitive decline in aging individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.