ArticleMarine drugs2011
Fucose-containing sulfated polysaccharides from brown seaweeds inhibit proliferation of melanoma cells and induce apoptosis by activation of caspase-3 in vitro.
Article in Marine drugs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 143 citations in OpenAlex.
- The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer.Integrative cancer therapies · 2018Trial
- Fucoidan and alginate from brown seaweeds: extraction, structural diversity, biocompatibility, biodegradability, and biomedical applications.Frontiers in plant science · 2026Review
- Harnessing Algae-Derived Bioactive Compounds for Sustainable and Effective Photoprotection in Skincare.Applied biochemistry and biotechnology · 2025Review
- Commercial importance of seaweeds: an overview.Bioresources and bioprocessing · 2025Review
- Davanat-Mimetic Galactomannan and Its Sulfated Derivative: Structure and Antitumor Effects against Melanoma.Biomacromolecules · 2025Article
- Anti-colorectal cancer effect and mechanism of a polysaccharide from Ruditapes philippinarum.European journal of nutrition · 2025Article
- Polysaccharide-Based Drug Carriers-A Patent Analysis.Gels (Basel, Switzerland) · 2024Review
- Systematic Characteristics of Fucoidan: Intriguing Features for New Pharmacological Interventions.International journal of molecular sciences · 2024Review
- Effect of Marine-Derived Saccharides on Human Skin Fibroblasts and Dermal Papilla Cells.Marine drugs · 2023Article
- Advanced Polymeric Membranes as Biomaterials Based on Marine Sources Envisaging the Regeneration of Human Tissues.Gels (Basel, Switzerland) · 2023Article
- Perspectives for the Use of Fucoidans in Clinical Oncology.International journal of molecular sciences · 2022Review
- Molecular mechanisms of anti-cancer bioactivities of seaweed polysaccharides.Chinese herbal medicines · 2022Review
- Characterization and Bioactivity of Polysaccharides Separated through a (Sequential) Biorefinery Process fromPolymers · 2022Article
- Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug-A Review.Molecules (Basel, Switzerland) · 2022Review
- Marine Compounds for Melanoma Treatment and Prevention.International journal of molecular sciences · 2022Review
- Phytochemical and Potential Properties of Seaweeds and Their Recent Applications: A Review.Marine drugs · 2022Review
- Complementarity of Raman and Infrared spectroscopy for rapid characterization of fucoidan extracts.Plant methods · 2021Article
- Extraction of Fucoidan fromACS omega · 2021Article
- Anti-Photoaging and Potential Skin Health Benefits of Seaweeds.Marine drugs · 2021Review
- In Vitro Antitumor Potential of Sulfated Polysaccharides from Seaweed Caulerpa cupressoides var. flabellata.Marine biotechnology (New York, N.Y.) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fucose-containing sulfated polysaccharides (FCSPs) extracted from seaweeds, especially brown macro-algae, are known to possess essential bioactive properties, notably growth inhibitory effects on tumor cells. In this work, we conducted a series of in vitro studies to examine the influence of FCSPs products from Sargassumhenslowianum C. Agardh (FSAR) and Fucus vesiculosus (FVES), respectively, on proliferation of melanoma B16 cells and to investigate the underlying apoptosis promoting mechanisms. Cell viability analysis showed that both FCSPs products, i.e., FSAR and FVES, decreased the proliferation of the melanoma cells in a dose-response fashion, with FSAR being more potent at lower dosages, and FVES being relatively more anti-proliferative than FSAR at higher dosages. Flow cytometric analysis by Annexin V staining of the melanoma cells exposed to the FCSPs products confirmed that both FSAR and FVES induced apoptosis. The FCSPs-induced apoptosis was evidenced by loss of plasma membrane asymmetry and translocation of the cell membrane phospholipids and was accompanied by the activation of caspase-3. The FCSPs bioactivity is proposed to be attributable to distinct structural features of the FCSPs, particularly the presence of sulfated galactofucans (notably in S.henslowianum) and sulfated fucans (notably in F. vesiculosus). This study thus indicates that unfractionated FCSPs may exert bioactive effects on skin cancer cells via induction of apoptosis through cascades of reactions that involve activation of caspase-3.
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