ArticleMarine drugs2012
Tasco®: a product of Ascophyllum nodosum enhances immune response of Caenorhabditis elegans against Pseudomonas aeruginosa infection.
Article in Marine drugs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Mechanisms ofMedicina (Kaunas, Lithuania) · 2026Review
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- Anti-infective potential of plant-derived quorum sensing inhibitors against multi-drug resistant human and aquatic bacterial pathogens.World journal of microbiology & biotechnology · 2023Article
- Article
- Prebiotic, Antioxidant, and Immunomodulatory Properties of Acidic Exopolysaccharide From MarineFrontiers in nutrition · 2021Article
- Article
- A Marine Actinomycete RescuesFrontiers in microbiology · 2017Article
- Beyond Traditional Antimicrobials: AFrontiers in microbiology · 2016Review
- Seamustard (Undaria pinnatifida) Improves Growth, Immunity, Fatty Acid Profile and Reduces Cholesterol in Hanwoo Steers.Asian-Australasian journal of animal sciences · 2014Article
- Selenite enhances immune response against Pseudomonas aeruginosa PA14 via SKN-1 in Caenorhabditis elegans.PloS one · 2014Article
- Full toxicity assessment of Genkwa Flos and the underlying mechanism in nematode Caenorhabditis elegans.PloS one · 2014Article
- Components of the cultivated red seaweed Chondrus crispus enhance the immune response of Caenorhabditis elegans to Pseudomonas aeruginosa through the pmk-1, daf-2/daf-16, and skn-1 pathways.Applied and environmental microbiology · 2013Article
- Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.International journal of molecular sciences · 2013Review
- The consumption of seaweed as a protective factor in the etiology of breast cancer: proof of principle.Journal of applied phycology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of Tasco®, a product made from the brown seaweed (Ascophyllum nodosum) were tested for the ability to protect Caenorhabditis elegans against Pseudomonas aeruginosa infection. A water extract of Tasco® (TWE) reduced P. aeruginosa inflicted mortality in the nematode. The TWE, at a concentration of 300 µg/mL, offered the maximum protection and induced the expression of innate immune response genes viz.; zk6.7 (Lypases), lys-1 (Lysozyme), spp-1 (Saponin like protein), f28d1.3 (Thaumatin like protein), t20g5.7 (Matridin SK domain protein), abf-1 (Antibacterial protein) and f38a1.5 (Lectin family protein). Further, TWE treatment also affected a number of virulence components of the P. aeuroginosa and reduced its secreted virulence factors such as lipase, proteases and toxic metabolites; hydrogen cyanide and pyocyanin. Decreased virulence factors were associated with a significant reduction in expression of regulatory genes involved in quorum sensing, lasI, lasR, rhlI and rhlR. In conclusion, the TWE-treatment protected the C. elegans against P. aeruginosa infection by a combination of effects on the innate immunity of the worms and direct effects on the bacterial quorum sensing and virulence factors.
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