Evidence map›Paper›PMID 22363018›Full record

ReviewVascular medicine (London, England)2012

Polyunsaturated fatty acids and peripheral artery disease.

S Marlene Grenon, Millie Hughes-Fulford, Joseph Rapp, Michael S Conte

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Vascular medicine (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01979874 phase2completednot on this mapstarted 2014, after this paper: background citation

The Effects of Omega-3 Fatty Acids Supplementation on Endothelial Function and Inflammation II

TypeinterventionalSponsorUniversity of California, San FranciscoRan2014 to 2017Enrolled26ConditionsPeripheral Arterial DiseaseArmsPro-Omega, ProOmega Placebo
NCT02096757 nacompletednot on this mapstarted 2014, after this paper: background citation

The Use of Fish Oil to Reduce Inflammation Caused by a Peripheral Vascular Intervention

TypeinterventionalSponsorUniversity of California, San FranciscoRan2014 to 2017Enrolled8ConditionsPeripheral Arterial DiseaseArmsPro-Omega, Pro-Omega Placebo
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Observational
  9. Lipids in preventive dentistry.Clinical oral investigations · 2013
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

S Marlene GrenonDivision of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94121, USA. marlene.grenon@ucsfmedctr.org
Millie Hughes-Fulford
Joseph Rapp
Michael S Conte
University of California, San Francisco · USSan Francisco VA Medical Center · US

Funding

CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
Suppression of the Immune Response in Spaceflight and AgingUH3AG037628 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI HUGHES-FULFORD, MILLIE · 2012 to 2014
$2.3M
NCRR NIH HHS KL2 RR024130NCRR NIH HHS KL2RR024130NIA NIH HHS UH3 AG037628
6 · The paper itself

Abstract

There is substantial evidence that polyunsaturated fatty acids (PUFAs) such as n-3 and n-6 fatty acids (FAs) play an important role in prevention of atherosclerosis. In vitro and in vivo studies focusing on the interactions between monocytes and endothelial cells have explored the molecular effects of FAs on these interactions. Epidemiological surveys, followed by large, randomized, control trials have demonstrated a reduction in major cardiovascular events with supplementation of n-3 FAs in secondary prevention settings. The evidence of beneficial effects specific to patients with peripheral artery disease (PAD) remains elusive, and is the focus of this review.

Indexed as

Dietary SupplementsCardiovascular DiseasesCausalityComorbidityEndothelial CellsFatty Acids, Omega-3Fatty Acids, Omega-6Fatty Acids, UnsaturatedFish OilsHumansMonocytesPeripheral Arterial DiseaseSecondary PreventionFatty Acids, Omega-3Fatty Acids, Omega-6Fatty Acids, UnsaturatedFish Oils

Identifiers

PMID22363018
PMCPMC5798884
OpenAlexW2159827079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.