ArticleScience (New York, N.Y.)2012
Evolution of shape by multiple regulatory changes to a growth gene.
Article in Science (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 69 citations in OpenAlex.
- Genome assembly and annotation of the parasitoid jewel wasp Nasonia oneida.Scientific data · 2025Article
- The roles of inter-tissue adhesion in development and morphological evolution.Journal of cell science · 2022Review
- Genetic, morphometric, and molecular analyses of interspecies differences in head shape and hybrid developmental defects in the wasp genus Nasonia.G3 (Bethesda, Md.) · 2021Article
- Genome Report: Whole Genome Sequence and Annotation of the Parasitoid Jewel WaspG3 (Bethesda, Md.) · 2020Article
- Article
- A major role for noncoding regulatory mutations in the evolution of enzyme activity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Evolution of Ovipositor Length in Drosophila suzukii Is Driven by Enhanced Cell Size Expansion and Anisotropic Tissue Reorganization.Current biology : CB · 2019Article
- Standing genetic variation in a tissue-specific enhancer underlies selfing-syndrome evolution in Capsella.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- OGS2: genome re-annotation of the jewel wasp Nasonia vitripennis.BMC genomics · 2016Article
- Dissection of the complex genetic basis of craniofacial anomalies using haploid genetics and interspecies hybrids in Nasonia wasps.Developmental biology · 2016Article
- Evolutionary Novelty in a Butterfly Wing Pattern through Enhancer Shuffling.PLoS biology · 2016Article
- Divergence in Patterns of Leaf Growth Polarity Is Associated with the Expression Divergence of miR396.The Plant cell · 2015Article
- Patterned Anchorage to the Apical Extracellular Matrix Defines Tissue Shape in the Developing Appendages of Drosophila.Developmental cell · 2015Article
- Review
- Mechanisms of bacterial morphogenesis: evolutionary cell biology approaches provide new insights.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- Behavior of Leaf Meristems and Their Modification.Frontiers in plant science · 2015Review
- Article
- The role of self-organization in developmental evolution.Theory in biosciences = Theorie in den Biowissenschaften · 2014Article
- Systematic perturbation of cytoskeletal function reveals a linear scaling relationship between cell geometry and fitness.Cell reports · 2014Article
- Emergence of tissue sensitivity to Hox protein levels underlies the evolution of an adaptive morphological trait.Developmental biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The genetic changes responsible for morphological differences between species are largely unidentified. Such changes can involve modifications of growth that are relevant to understanding evolution, development, and disease. We identified a gene that induces male-specific wing size and shape differences between Nasonia wasp species. Fine-scale mapping and in situ hybridization reveal that changes in at least three regions (two strictly in noncoding sequence) around the gene unpaired-like (upd-like) cause changes in spatial and temporal expression of upd-like in the developing wing and corresponding changes in wing width. Upd-like shows homology to the Drosophila unpaired gene, a well-studied signaling protein that regulates cell proliferation and differentiation. Our results indicate how multiple changes in the regulation of upd-like are involved in microevolution of morphological and sex-specific differences between species.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.