ArticleChemical senses2012
Residual chemoresponsiveness to acids in the superior laryngeal nerve in "taste-blind" (P2X2/P2X3 double-KO) mice.
Article in Chemical senses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 46 citations in OpenAlex.
- Taste dysfunction in Long COVID.bioRxiv : the preprint server for biology · 2025Article
- Review
- The New Wave of Blocking Taste.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Dual functions of SNAP25 in mouse taste buds.The Journal of physiology · 2025Article
- Safety, Tolerability, and Pharmacokinetics of Filapixant, a Highly Selective P2X3 Receptor Antagonist, in an Ascending-Single-Dose First-in-Human Study.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Give-and-take of gustation: the interplay between gustatory neurons and taste buds.Chemical senses · 2024Review
- The elusive cephalic phase insulin response: triggers, mechanisms, and functions.Physiological reviews · 2023Review
- TRPA1s act as chemosensors but not as cold sensors or mechanosensors to trigger the swallowing reflex in rats.Scientific reports · 2022Article
- Internal senses of the vagus nerve.Neuron · 2022Review
- The Cellular and Molecular Basis of Sour Taste.Annual review of physiology · 2022Review
- The Role of ATP and Purinergic Receptors in Taste Signaling.Handbook of experimental pharmacology · 2022Review
- Morphology of GNAT3-immunoreactive chemosensory cells in the nasal cavity and pharynx of the rat.Journal of anatomy · 2021Article
- Glucagon-Like Peptide 1 and Taste Perception: From Molecular Mechanisms to Potential Clinical Implications.International journal of molecular sciences · 2021Review
- Genetic Deletion of TrpV1 and TrpA1 Does Not Alter Avoidance of or Patterns of Brainstem Activation to Citric Acid in Mice.Chemical senses · 2020Article
- The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity.Cellular and molecular life sciences : CMLS · 2020Review
- Targeting Chemosensory Ion Channels in Peripheral Swallowing-Related Regions for the Management of Oropharyngeal Dysphagia.International journal of molecular sciences · 2020Review
- Sugar causes obesity and metabolic syndrome in mice independently of sweet taste.American journal of physiology. Endocrinology and metabolism · 2020Article
- Article
- Transient receptor potential vanilloid 4 mediates sour taste sensing via type III taste cell differentiation.Scientific reports · 2019Article
- Mouse Parabrachial Neurons Signal a Relationship between Bitter Taste and Nociceptive Stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Mice lacking both the P2X2 and the P2X3 purinergic receptors (P2X-dblKO) exhibit loss of responses to all taste qualities in the taste nerves innervating the tongue. Similarly, these mice exhibit a near total loss of taste-related behaviors in brief access tests except for a near-normal avoidance of acidic stimuli. This persistent avoidance of acids despite the loss of gustatory neural responses to sour was postulated to be due to continued responsiveness of the superior laryngeal (SL) nerve. However, chemoresponses of the larynx are attributable both to taste buds and to free nerve endings. In order to test whether the SL nerve of P2X-dblKO mice remains responsive to acids but not to other tastants, we recorded responses from the SL nerve in wild-type (WT) and P2X-dblKO mice. WT mice showed substantial SL responses to monosodium glutamate, sucrose, urea, and denatonium-all of which were essentially absent in P2X-dblKO animals. In contrast, the SL nerve of P2X-dblKO mice exhibited near-normal responses to citric acid (50 mM) although responsiveness of both the chorda tympani and the glossopharyngeal nerves to this stimulus were absent or greatly reduced. These results are consistent with the hypothesis that the residual avoidance of acidic solutions by P2X-dblKO mice may be attributable to the direct chemosensitivity of nerve fibers innervating the laryngeal epithelium and not to taste.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.