ArticleChemical senses2012
A genome-wide study on the perception of the odorants androstenone and galaxolide.
Article in Chemical senses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 36 citations in OpenAlex.
- Ambient Air Pollution and Smell Function: Evidence from the National Geographic Smell Survey.medRxiv : the preprint server for health sciences · 2025Article
- From musk to body odor: Decoding olfaction through genetic variation.PLoS genetics · 2022Article
- Article
- Anosmia-A Clinical Review.Chemical senses · 2017Review
- A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior.Translational psychiatry · 2017Article
- Mammalian odorant receptors: functional evolution and variation.Current opinion in neurobiology · 2015Review
- Global Survey of Variation in a Human Olfactory Receptor Gene Reveals Signatures of Non-Neutral Evolution.Chemical senses · 2015Article
- Genetic basis of olfactory cognition: extremely high level of DNA sequence polymorphism in promoter regions of the human olfactory receptor genes revealed using the 1000 Genomes Project dataset.Frontiers in psychology · 2014Article
- Genetic analysis of chemosensory traits in human twins.Chemical senses · 2012Article
- An olfactory demography of a diverse metropolitan population.BMC neuroscience · 2012Article
- Personal receptor repertoires: olfaction as a model.BMC genomics · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
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Abstract
Twin pairs and their siblings rated the intensity of the odorants amyl acetate, androstenone, eugenol, Galaxolide, mercaptans, and rose (N = 1573). Heritability was established for ratings of androstenone (h (2) = 0.30) and Galaxolide (h(2) = 0.34) but not for the other odorants. Genome-wide association analysis using 2.3 million single nucleotide polymorphisms indicated that the most significant association was between androstenone and a region without known olfactory receptor genes (rs10966900, P = 1.2 × 10(-7)). A previously reported association between the olfactory receptor OR7D4 and the androstenone was not detected until we specifically typed this gene (P = 1.1 × 10(-4)). We also tested these 2 associations in a second independent sample of subjects and replicated the results either fully (OR7D4, P = 0.00002) or partially (rs10966900, P = 0.010; N = 266). These findings suggest that 1) the perceived intensity of some but not all odorants is a heritable trait, 2) use of a current genome-wide marker panel did not detect a known olfactory genotype-phenotype association, and 3) person-to-person differences in androstenone perception are influenced by OR7D4 genotype and perhaps by variants of other genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.