ArticleThe Journal of biological chemistry2012
Identification of multicomponent histidine-aspartate phosphorelay system controlling flagellar and motility gene expression in Geobacter species.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Evolution for enhanced extracellular electron transfer inFrontiers in microbiology · 2026Article
- Cytochrome OmcS Is Not Essential for Extracellular Electron Transport via Conductive Pili in Geobacter sulfurreducens Strain KN400.Applied and environmental microbiology · 2022Article
- Electromicrobiology: the ecophysiology of phylogenetically diverse electroactive microorganisms.Nature reviews. Microbiology · 2022Review
- Comparative insights into genome signatures of ferric iron oxide- and anode-stimulated Desulfuromonas spp. strains.BMC genomics · 2021Article
- Cytochromes in Extracellular Electron Transfer inApplied and environmental microbiology · 2021Review
- Article
- The unphosphorylated form of the PilR two-component system regulates pilA gene expression in Geobacter sulfurreducens.Environmental science and pollution research international · 2017Article
- Scarless Genome Editing and Stable Inducible Expression Vectors for Geobacter sulfurreducens.Applied and environmental microbiology · 2015Article
- Genome sequence of a dissimilatory Fe(III)-reducing bacterium Geobacter soli type strain GSS01(T).Standards in genomic sciences · 2015Article
- Link between capacity for current production and syntrophic growth in Geobacter species.Frontiers in microbiology · 2015Article
- Going wireless: Fe(III) oxide reduction without pili by Geobacter sulfurreducens strain JS-1.Applied and environmental microbiology · 2014Article
- Exploring the role of CheA3 in Desulfovibrio vulgaris Hildenborough motility.Frontiers in microbiology · 2014Article
- Outer cell surface components essential for Fe(III) oxide reduction by Geobacter metallireducens.Applied and environmental microbiology · 2013Article
- Characterizing the interplay between multiple levels of organization within bacterial sigma factor regulatory networks.Nature communications · 2013Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Geobacter species play an important role in the natural biogeochemical cycles of aquatic sediments and subsurface environments as well as in subsurface bioremediation by oxidizing organic compounds with the reduction of insoluble Fe(III) oxides. Flagellum-based motility is considered to be critical for Geobacter species to locate fresh sources of Fe(III) oxides. Functional and comparative genomic approaches, coupled with genetic and biochemical methods, identified key regulators for flagellar gene expression in Geobacter species. A master transcriptional regulator, designated FgrM, is a member of the enhancer-binding protein family. The fgrM gene in the most studied strain of Geobacter species, Geobacter sulfurreducens strain DL-1, is truncated by a transposase gene, preventing flagellar biosynthesis. Integrating a functional FgrM homolog restored flagellar biosynthesis and motility in G. sulfurreducens DL-1 and enhanced the ability to reduce insoluble Fe(III) oxide. Interrupting the fgrM gene in G. sulfurreducens strain KN400, which is motile, removed the capacity for flagellar production and inhibited Fe(III) oxide reduction. FgrM, which is also a response regulator of the two-component His-Asp phosphorelay system, was phosphorylated by histidine kinase GHK4, which was essential for flagellar production and motility. GHK4, which is a hybrid kinase with a receiver domain at the N terminus, was phosphorylated by another histidine kinase, GHK3. Therefore, the multicomponent His-Asp phosphorelay system appears to control flagellar gene expression in Geobacter species.
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