ArticleNorth American journal of medical sciences2011
The antiatherogenic, renal protective and immunomodulatory effects of purslane, pumpkin and flax seeds on hypercholesterolemic rats.
Article in North American journal of medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 72 citations in OpenAlex.
- Clinical Effects of Portulaca Oleracea Seeds on Dyslipidemia in Obese Adolescents: a Triple-blinded Randomized Controlled Trial.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2014Trial
- Nutraceutical Impact of Pumpkin Seed Oil on Expression Levels of EZH-2 and KRT-14 Genes against DSS-induced Inflammatory Bowel Disease in the Rat Model.Cell biochemistry and biophysics · 2025Article
- Pumpkin and Pumpkin By-Products: A Comprehensive Overview of Phytochemicals, Extraction, Health Benefits, and Food Applications.Foods (Basel, Switzerland) · 2024Review
- Herbal Medicine- A Friend or a Foe of Cardiovascular Disease.Cardiovascular & hematological agents in medicinal chemistry · 2024Review
- Cookies enriched with anethole and secoisolariciresinol diglucoside from flaxseed and fennel seeds improve hypercholesterolemia, lipid profile, and liver functions: A pilot study.Food science & nutrition · 2023Article
- Phytochemical Characteristics and Anti-Inflammatory, Immunoregulatory, and Antioxidant Effects ofEvidence-based complementary and alternative medicine : eCAM · 2023Review
- Effects ofIranian journal of basic medical sciences · 2022Review
- Protective Effect ofMolecules (Basel, Switzerland) · 2022Article
- Nutritional Value, Phytochemical Potential, and Therapeutic Benefits of Pumpkin (Plants (Basel, Switzerland) · 2022Review
- Age-related changes in haematological parameters and biochemical markers of healing in the stomach of rats with acetic acid induced injury.Toxicology reports · 2020Article
- Hepatoprotective and Renoprotective Properties of Lovastatin-Loaded Ginger and Garlic Oil Nanoemulsomes: Insights into Serum Biological Parameters.Medicina (Kaunas, Lithuania) · 2019Article
- A Pharmacological Review onJournal of pharmacopuncture · 2019Review
- Article
- Diuretic and antioxidant activities of the aqueous extract of leaves of Vepris heterophylla (Engl.) R. Let (Rutaceae) in rats.BMC complementary and alternative medicine · 2016Article
- Flax and flaxseed oil: an ancient medicine & modern functional food.Journal of food science and technology · 2014Review
- Immunomodulatory activity of aged garlic extract against implanted fibrosarcoma tumor in mice.North American journal of medical sciences · 2013Article
- The effects of propolis supplementation on metabolic parameters: A systematic review and meta-analysis of randomized controlled clinical trials.Avicenna journal of phytomedicineReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtherosclerosis remains one of the leading causes of death all over the world. Flax, pumpkin and purslane seeds are rich sources of unsaturated fatty acids, antioxidants and fibers, known to have antiatherogenic activities.
aimsThis study was to examine the efficiency of using either flax/pumpkin or purslane/pumpkin seed mixture (components of ω-3 and ω-6) on hyperlipidemia, kidney function and as immunomodulators in rats fed high cholesterol diets. MATERIALS AND
methods40 male albino rats were divided into four groups: control group, hypercholesterolemic rats, fed the balanced diet supplemented with cholesterol at a dose level of 2 g/100 g diet; the other two groups of animals fed the same previous hypercholesterolemic diet supplemented with either flax/pumpkin seed mixture or pumpkin/purslane seed mixture at ratio of (5/1) (ω-3 and ω-6).
resultsThe present study showed that 2% cholesterol administration caused a significant increase in total cholesterol, total lipids, and triacylglycerol in both serum and liver. Serum phospholipids, LDL-C, and atherogenic index AI also significantly increased compared to control group. Cholesterol-enriched diet significantly increased serum urea, creatinine, sodium and potassium levels as well as significantly increased serum IgG and IgM compared to healthy control. Consumption of flax/pumpkin or purslane/pumpkin seed mixtures by hypercholesterolemic rats resulted in a significantly decrement in lipid parameters and significant improvement in IgG and IgM levels as compared with hypercholesterolemic rats.
conclusionOur results suggests that both flax/pumpkin and purslane/pumpkin seed mixtures had anti-atherogenic hypolipidemic and immunmodulator effects which were probably mediated by unsaturated fatty acids (including alpha linolenic acid) present in seed mixture.
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