Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2012
Reactive hyperemia is not responsible for stimulating muscle protein synthesis following blood flow restriction exercise.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00891696 (Nutritional and Contractile Regulation of Muscle Growth), which is not on this map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nutritional and Contractile Regulation of Muscle Growth (Cycle 2)
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Effectiveness of Blood Flow Restriction on Functionality, Quality of Life and Pain in Patients with Neuromusculoskeletal Pathologies: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Pooled it
- Effects of blood flow restriction without additional exercise on strength reductions and muscular atrophy following immobilization: A systematic review.Journal of sport and health science · 2020Pooled it
- Blood Flow Restriction Therapy Preserves Lower Extremity Bone and Muscle Mass After ACL Reconstruction.Sports health · 2023Trial
- Blood Flow Restriction Only Increases Myofibrillar Protein Synthesis with Exercise.Medicine and science in sports and exercise · 2019Trial
- Blood flow restriction late in recovery after heavy resistance exercise hampers muscle recuperation.European journal of applied physiology · 2018Trial
- Acute low-intensity cycling with blood-flow restriction has no effect on metabolic signaling in human skeletal muscle compared to traditional exercise.European journal of applied physiology · 2017Trial
- Effects of a pre-workout supplement on hyperemia following leg extension resistance exercise to failure with different resistance loads.Journal of the International Society of Sports Nutrition · 2017Trial
- Post-exercise blood flow restriction attenuates muscle hypertrophy.European journal of applied physiology · 2016Trial
- Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin.American journal of physiology. Endocrinology and metabolism · 2014Trial
- Pressure point: blood flow restriction exercise and the pain paradox in musculoskeletal injury and persistent pain populations-a narrative review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Effects of Blood Flow Restriction Training on Cardiopulmonary Function and Body Composition: A Systematic Review with Meta-Analysis.Journal of human kinetics · 2026Review
- Muscle hypertrophy and strength improvements following blood flow restriction combined with resistance training in team-athletes: a systematic review and meta-analysis.Frontiers in physiology · 2026Article
- Daily blood flow restriction does not preserve muscle mass and strength during 2 weeks of bed rest.The Journal of physiology · 2025Article
- Acute neuromuscular, cardiovascular, and muscle oxygenation responses to low-intensity aerobic interval exercises with blood flow restriction.Experimental physiology · 2024Article
- Blood flow restriction training activates the muscle metaboreflex during low-intensity sustained exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Effects of blood flow restriction (BFR) with resistance exercise on musculoskeletal health in older adults: a narrative review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2022Review
- Muscle Adaptations to Heavy-Load and Blood Flow Restriction Resistance Training Methods.Frontiers in physiology · 2022Article
- Exercise adherence-related perceptual responses to low-load blood flow restriction resistance exercise in young adults: A pilot study.Physiological reports · 2021Article
- Blood flow restriction in human skeletal muscle during rest periods after high-load resistance training down-regulates miR-206 and induces Pax7.Journal of sport and health science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Blood flow restriction (BFR) to contracting skeletal muscle during low-intensity resistance exercise training increases muscle strength and size in humans. However, the mechanism(s) underlying these effects are largely unknown. We have previously shown that mammalian target of rapamycin complex 1 (mTORC1) signaling and muscle protein synthesis (MPS) are stimulated following an acute bout of BFR exercise. The purpose of this study was to test the hypothesis that reactive hyperemia is the mechanism responsible for stimulating mTORC1 signaling and MPS following BFR exercise. Six young men (24 ± 2 yr) were used in a randomized crossover study consisting of two exercise trials: low-intensity resistance exercise with BFR (BFR trial) and low-intensity resistance exercise with sodium nitroprusside (SNP), a pharmacological vasodilator infusion into the femoral artery immediately after exercise to simulate the reactive hyperemia response after BFR exercise (SNP trial). Postexercise mixed-muscle fractional synthetic rate from the vastus lateralis increased by 49% in the BFR trial (P < 0.05) with no change in the SNP trial (P > 0.05). BFR exercise increased the phosphorylation of mTOR, S6 kinase 1, ribosomal protein S6, ERK1/2, and Mnk1-interacting kinase 1 (P < 0.05) with no changes in mTORC1 signaling in the SNP trial (P > 0.05). We conclude that reactive hyperemia is not a primary mechanism for BFR exercise-induced mTORC1 signaling and MPS. Further research is necessary to elucidate the cellular mechanism(s) responsible for the increase in mTOR signaling, MPS, and hypertrophy following acute and chronic BFR exercise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.