ArticleWorld journal of surgery2012
Ectopic hormone-secreting pheochromocytoma: a francophone observational study.
Article in World journal of surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Ectopic ACTH Syndrome Caused by Pheochromocytoma: A Case Report and Systematic Review.Endocrine, metabolic & immune disorders drug targets · 2026Pooled it
- Single-cell transcriptomics reveals transcriptional reprogramming and microenvironmental remodeling in ectopic ACTH/CRH-secreting pheochromocytomas.Journal of translational medicine · 2026Article
- Composite pheochromocytoma-ganglioneuroma secreting vasoactive intestinal peptide.Endocrinology, diabetes & metabolism case reports · 2026Article
- The Role of Cortisol Secretion in Pheochromocytomas and Paragangliomas: Clinical and Perioperative Implications.The Journal of clinical endocrinology and metabolism · 2026Article
- Approach to Endocrine Hypertension: A Case-Based Discussion.Current hypertension reports · 2025Review
- A Pheochromocytoma With Adrenocorticotropic Hormone Secretion and Subsequent Fatal Outcome: A Case Report.Cureus · 2025Article
- A rare cause of severe Cushing's syndrome.Endocrinology, diabetes & metabolism case reports · 2020Article
- Adrenocorticotropic hormone-producing pheochromocytoma: A case report.International journal of surgery case reports · 2020Article
- A Case of Von Hippel-Lindau Disease with Bilateral Pheochromocytoma and Ectopic Hypersecretion of Intact Parathyroid Hormone in an Adolescent Girl.Case reports in endocrinology · 2020Article
- Malignant Pheochromocytomas/Paragangliomas and Ectopic Hormonal Secretion: A Case Series and Review of the Literature.Cancers · 2019Review
- AZD8055 inhibits ACTH secretion in a case of bilateral ACTH-secreting pheochromocytoma.Oncology letters · 2018Article
- [Ectopia of the adrenal].Der Pathologe · 2018Review
- Adrenocorticotropic Hormone Secreting Pheochromocytoma Underlying Glucocorticoid Induced Pheochromocytoma Crisis.Case reports in endocrinology · 2018Article
- Frequency of Cushing's syndrome due to ACTH-secreting adrenal medullary lesions: a retrospective study over 10 years from a single center.Endocrine · 2017Article
- Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.The Journal of clinical endocrinology and metabolism · 2016Article
- Bowel perforation complicating an ACTH-secreting phaeochromocytoma.Endocrinology, diabetes & metabolism case reports · 2016Article
- Phaeochromocytoma with hypercortisolism and hypercalcaemia.BMJ case reports · 2015Article
- Adrenal insufficiency in a child following unilateral excision of a dual-hormone secreting phaeochromocytoma.Endocrinology, diabetes & metabolism case reports · 2015Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEctopic hormone-secreting pheochromocytomas are rare; only case reports exist in the literature. This condition has been linked with increased malignancy, familial syndromes, and ACTH secretion. We wanted to test these hypotheses and shed light on the nature of ectopic hormone-secreting pheochromocytomas.
methodsThis is a multicenter (francophone) observational study. Inclusion was based upon abnormal preoperative hormone tests in patients with pheochromocytoma that normalized after removal of the tumor. Where possible, immunohistochemistry was performed to confirm that ectopic secretion came from the tumor.
resultsSixteen cases were found: nine female and seven male patients. Median age was 50.5 (range 31-89) years. Most presented with hypertension, diabetes, or cushingoid features. Ten patients had specific symptoms from the ectopic hormone secretion. Two had a familial syndrome. Of eight patients with excess cortisol secretion, three died as a result of the tumor resection: two had pheochromocytomas >15 cm and their associated cortisol hypersecretion complicated their postoperative course. The other died from a torn subhepatic vein. The 13 survivors did not develop any evidence of malignancy during follow-up (median 50 months). Symptoms from the ectopic secretion resolved after removal of the tumor. Immunohistochemistry was performed and was positive in eight tumors: five ACTH, three calcitonins, and one VIP.
conclusionsMost pheochromocytomas with ectopic secretion are neither malignant nor familial. Most ectopic hormone-secreting pheochromocytoma cause hypercortisolemia. Patients with a pheochromocytoma should be worked up for ectopic hormones, because removal of the pheochromocytoma resolves those symptoms. Associated cortisol secretion needs careful attention.
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