SynthesisDiabetologia2012
Treatment of acute Charcot foot with bisphosphonates: a systematic review of the literature.
Synthesis in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Efficacy of medical treatment for Charcot neuroarthropathy: a systematic review and meta-analysis of randomized controlled trials.Acta diabetologica · 2021Pooled it
- Trial
- Burning Issues/Hot Topics: The Charcot Foot.Journal of clinical medicine · 2026Review
- What the Physician Needs to Know about Charcot Arthropathy and Ankle Fracture Treatment Dilemma: A Case Report and a Possible Medical Approach and Treatment Algorithm.Journal of orthopaedic case reports · 2024Article
- RANKL-RANK-OPG Pathway in Charcot Diabetic Foot: Pathophysiology and Clinical-Therapeutic Implications.International journal of molecular sciences · 2023Review
- An overview of Charcot's neuroarthropathy.Journal of clinical & translational endocrinology · 2020Review
- Charcot arthropathy of the diabetic foot in a sub-Saharan tertiary hospital: a cross-sectional study.Journal of foot and ankle research · 2019Article
- Updates on Diabetic Foot and Charcot Osteopathic Arthropathy.Current diabetes reports · 2018Review
- Role of bisphosphonates in the management of acute Charcot foot.World journal of diabetes · 2018Review
- New trends in the orthopaedic management of diabetic foot.EFORT open reviews · 2018Article
- Salient features and outcomes of Charcot foot - An often-overlooked diabetic complication: A 17-year-experience at a diabetic center in Bangkok.Journal of clinical & translational endocrinology · 2018Article
- An uncommon cause of warm foot.BMJ case reports · 2017Article
- Diabetic charcot neuroarthropathy: prevalence, demographics and outcome in a regional referral centre.Irish journal of medical science · 2017Article
- Neuroarthropathy of the foot revealing primary systemic amyloidosis: case report and literature review.Clinical rheumatology · 2016Review
- A literature-based guide to the conservative and surgical management of the acute Charcot foot and ankle.Diabetic foot & ankle · 2015Article
- Developing an evidence-based clinical pathway for the assessment, diagnosis and management of acute Charcot Neuro-Arthropathy: a systematic review.Journal of foot and ankle research · 2013Article
- Rheumatic conditions in patients with diabetes mellitus.Clinical rheumatology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aim/hypothesisWe undertook a systematic review of the literature concerning the efficacy and safety of bisphosphonates in acute Charcot neuropathic osteoarthropathy.
methodsMEDLINE, PubMed, the Cochrane Database of Systematic Reviews, and abstracts presented during the meetings of the American Diabetes Association and the European Association of Diabetes were searched for relevant publications from the period January 1990 to September 2011.
resultsA total of ten studies on the treatment of acute Charcot osteoarthropathy with bisphosphonates were identified and included in the analysis. Only four clinical trials were published, three of which were randomised. Bisphosphonates appeared to induce significant reductions in skin temperature and bone turnover markers compared with placebo, without serious adverse events. Nevertheless, bisphosphonates did not shorten the immobilisation time. Moreover, no data were available regarding their long-term effects. CONCLUSIONS/INTERPRETATIONS: Bisphosphonates have been shown to be effective for reducing bone turnover markers and skin temperature in some studies. Nevertheless, the long-term efficacy, specifically that regarding the occurrence of deformities and ulcerations, remains to be demonstrated as no follow-up studies have been published. Moreover, some studies have suggested that bisphosphonates may lengthen the resolution phase of the disease. In our opinion, the data are too weak to support the use of bisphosphonates as a routine treatment for acute Charcot neuroarthropathy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.