ArticleJournal of neural engineering2012
Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies.
Article in Journal of neural engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- Opportunities and Challenges of Brain-on-a-Chip Interfaces.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Neuronal innervation regulates the secretion of neurotrophic myokines and exosomes from skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Theta rhythm-like bidirectional cycling dynamics of living neuronal networks in vitro.PloS one · 2018Article
- Cortical Network Synchrony Under Applied Electrical FieldFrontiers in neuroscience · 2018Article
- Dopamine-dependent effects on basal and glutamate stimulated network dynamics in cultured hippocampal neurons.Journal of neurochemistry · 2017Article
- A Simplified In vitro Experimental Model Encompasses the Essential Features of Sleep.Frontiers in neuroscience · 2016Article
- Feed-Forward Propagation of Temporal and Rate Information between Cortical Populations during Coherent Activation in Engineered In Vitro Networks.Frontiers in neural circuits · 2016Article
- Article
- Network dynamics of 3D engineered neuronal cultures: a new experimental model for in-vitro electrophysiology.Scientific reports · 2014Article
- Effects of antiepileptic drugs on hippocampal neurons coupled to micro-electrode arrays.Frontiers in neuroengineering · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Slow wave oscillations in the brain are essential for coordinated network activity but have not been shown to self-organize in vitro. Here, the development of dissociated hippocampal neurons into an active network with oscillations on multi-electrode arrays was evaluated in the absence and presence of chronic external stimulation. Significant changes in signal power were observed in the range of 1-400 Hz with an increase in amplitude during bursts. Stimulation increased oscillatory activity primarily in the theta (4-11 Hz) and slow gamma (30-55 Hz) bands. Spikes were most prominently phase-locked to the slow gamma waves. Notably, the dissociated network self-organized to exhibit sustained delta, theta, beta and gamma oscillations without input from cortex, thalamus or organized pyramidal cell layers.
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