ArticleBritish journal of cancer2012
Hedgehog pathway activation in human transitional cell carcinoma of the bladder.
Article in British journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- HOXB4 Promotes Bladder Cancer Progression in Part Through Transcriptional Activation of Smoothened.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Phytochemicals as Chemo-Preventive and Therapeutic Agents Against Bladder Cancer: A Comprehensive Review.Diseases (Basel, Switzerland) · 2025Review
- Hedgehog signaling mechanism and role in cancer.Seminars in cancer biology · 2022Review
- Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer.Cells · 2022Review
- Article
- Hedgehog Signaling and Truncated GLI1 in Cancer.Cells · 2020Review
- A novel tumor suppressing gene,Oncology letters · 2020Article
- MicroRNAs: Key Players in Bladder Cancer.Molecular diagnosis & therapy · 2019Review
- Possible correlation of sonic hedgehog signaling with epithelial-mesenchymal transition in muscle-invasive bladder cancer progression.Journal of cancer research and clinical oncology · 2019Article
- Gene Expression Analyses in Non Muscle Invasive Bladder Cancer Reveals a Role for Alternative Splicing and Tp53 Status.Scientific reports · 2019Article
- Sonic Hedgehog Expression is Associated with Lymph Node Invasion in Urothelial Bladder Cancer.Pathology oncology research : POR · 2019Article
- Collagen stiffness promoted non-muscle-invasive bladder cancer progression to muscle-invasive bladder cancer.OncoTargets and therapy · 2019Article
- Targeting GLI Transcription Factors in Cancer.Molecules (Basel, Switzerland) · 2018Review
- Downregulation of FoxM1 inhibits cell growth and migration and invasion in bladder cancer cells.American journal of translational research · 2018Article
- Effect of estrogen receptor β agonists on proliferation and gene expression of ovarian cancer cells.BMC cancer · 2017Article
- Understanding the biology of urothelial cancer metastasis.Asian journal of urology · 2016Review
- Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis.Oncology letters · 2016Article
- Acetylation of FOXM1 is essential for its transactivation and tumor growth stimulation.Oncotarget · 2016Article
- Article
- Meta-analysis of microRNAs as biomarkers for muscle-invasive bladder cancer.Biomedical reports · 2016Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Hedgehog (Hh) signalling pathway functions as an organiser in embryonic development. Recent studies have shown constitutive activation of this pathway in various malignancies, but its role in bladder cancer remains poorly studied.
methodsExpression levels of 31 genes and 9 microRNAs (miRNAs) involved in the Hh pathway were determined by quantitative real-time RT-PCR in 71 bladder tumour samples (21 muscle-invasive (MIBC) and 50 non-muscle-invasive (NMIBC) bladder cancers), as well as in 6 bladder cancer cell lines.
resultsThe SHH ligand gene and Gli-inducible target genes (FOXM1, IGF2, OSF2, H19, and SPP1) were overexpressed in tumour samples as compared with normal bladder tissue. SHH overexpression was found in 96% of NMIBC and 52% of MIBC samples, as well as in two bladder cancer cell lines. Altered expression of miRNAs supported their oncogene or tumour-suppressor gene status. In univariate analysis, high expression levels of PTCH2, miRNA-92A, miRNA-19A, and miRNA-20A were associated with poorer overall survival in MIBC (P=0.02, P=0.012, P=0.047, and P=0.036, respectively).
conclusionWe observed constitutive activation of the Hh pathway in most NMIBC and about 50% of MIBC. We also found that some protein-coding genes and miRNAs involved in the Hh pathway may have prognostic value at the individual level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.