ArticleBMC research notes2012
Conserved requirement for DEAD-box RNA helicase Gemin3 in Drosophila oogenesis.
Article in BMC research notes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Conserved differential expression of DDX helicase and CPEB genes in skeletal muscles potentially influences neuromuscular junctions during aging: a computational analysis.Biogerontology · 2026Article
- Diverse roles of stress-responsive RNP granules in oogenesis and infertility.Biology of reproduction · 2025Review
- An Interaction Network of RNA-Binding Proteins Involved inMolecular & cellular proteomics : MCP · 2020Article
- Genetic screen identifies a requirement for SMN in mRNA localisation within the Drosophila oocyte.BMC research notes · 2018Article
- Loss of the Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis.Developmental biology · 2015Article
- Gem depletion: amyotrophic lateral sclerosis and spinal muscular atrophy crossover.CNS neuroscience & therapeutics · 2014Review
- GEMINs: potential therapeutic targets for spinal muscular atrophy?Frontiers in neuroscience · 2014Review
- Prp22 and spliceosome components regulate chromatin dynamics in germ-line polyploid cells.PloS one · 2013Article
- The Gemin associates of survival motor neuron are required for motor function in Drosophila.PloS one · 2013Article
- Effects of stress and aging on ribonucleoprotein assembly and function in the germ line.Wiley interdisciplinary reviews. RNAReview
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDEAD-box RNA helicase Gemin3 is an essential protein since its deficiency is lethal in both vertebrates and invertebrates. In addition to playing a role in transcriptional regulation and RNA silencing, as a core member of the SMN (survival of motor neurons) complex, Gemin3 is required for the biogenesis of spliceosomal snRNPs (small nuclear ribonucleoproteins), and axonal mRNA metabolism. Studies in the mouse and C. elegans revealed that loss of Gemin3 function has a negative impact on ovarian physiology and development.
findingsThis work reports on the generation and characterisation of gemin3 mutant germline clones in Drosophila adult females. Gemin3 was found to be required for the completion of oogenesis and its loss led to egg polarity defects, oocyte mislocalisation, and abnormal chromosome morphology. Canonical Cajal bodies were absent in the majority of gemin3 mutant egg chambers and histone locus bodies displayed an atypical morphology. snRNP distribution was perturbed so that on gemin3 loss, snRNP cytoplasmic aggregates (U bodies) were only visible in wild type.
conclusionsThese findings establish a conserved requirement for Gemin3 in Drosophila oogenesis. Furthermore, in view of the similarity to the phenotypes described previously in smn mutant germ cells, the present results confirm the close functional relationship between SMN and Gemin3 on a cellular level.
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